Sarkar D, Fisher PB: Molecular mechanisms of aging-associated inflammation. Cancer Lett. 2006, 236 (1): 13-23. 10.1016/j.canlet.2005.04.009.
Article
CAS
PubMed
Google Scholar
Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C: Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing. 2005, 2: 8-10.1186/1742-4933-2-8.
Article
PubMed Central
PubMed
Google Scholar
Yung RL: Changes in immune function with age. Rheum Dis Clin North Am. 2000, 26 (3): 455-473. 10.1016/S0889-857X(05)70151-4.
Article
CAS
PubMed
Google Scholar
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T: Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev. 2007
Google Scholar
Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S: Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007, 128 (1): 92-105. 10.1016/j.mad.2006.11.016.
Article
CAS
PubMed
Google Scholar
Krtolica A, Campisi J: Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol. 2002, 34 (11): 1401-1414. 10.1016/S1357-2725(02)00053-5.
Article
CAS
PubMed
Google Scholar
Mariotti M, Castiglioni S, Bernardini D, Maier JA: Interleukin 1 alpha is a marker of endothelial cellular senescent. Immun Ageing. 2006, 3: 4-10.1186/1742-4933-3-4.
Article
PubMed Central
PubMed
Google Scholar
Shelton DN, Chang E, Whittier PS, Choi D, Funk WD: Microarray analysis of replicative senescence. Curr Biol. 1999, 9 (17): 939-945. 10.1016/S0960-9822(99)80420-5.
Article
CAS
PubMed
Google Scholar
Zhang H, Pan KH, Cohen SN: Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc Natl Acad Sci U S A. 2003, 100 (6): 3251-3256. 10.1073/pnas.2627983100.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ly DH, Lockhart DJ, Lerner RA, Schultz PG: Mitotic misregulation and human aging. Science. 2000, 287 (5462): 2486-2492. 10.1126/science.287.5462.2486.
Article
CAS
PubMed
Google Scholar
Geigl JB, Langer S, Barwisch S, Pfleghaar K, Lederer G, Speicher MR: Analysis of gene expression patterns and chromosomal changes associated with aging. Cancer Res. 2004, 64 (23): 8550-8557. 10.1158/0008-5472.CAN-04-2151.
Article
CAS
PubMed
Google Scholar
Coller HA, Sang L, Roberts JM: A new description of cellular quiescence. PLoS Biol. 2006, 4 (3): e83-10.1371/journal.pbio.0040083.
Article
PubMed Central
PubMed
Google Scholar
Young MB, DiSilvestro MR, Sendera TJ, Freund J, Kriete A, Magnuson SR: Analysis of gene expression in carbon tetrachloride-treated rat livers using a novel bioarray technology. Pharmacogenomics J. 2003, 3 (1): 41-52. 10.1038/sj.tpj.6500147.
Article
CAS
PubMed
Google Scholar
Canales RD, Luo Y, Willey JC, Austermiller B, Barbacioru CC, Boysen C, Hunkapiller K, Jensen RV, Knight CR, Lee KY, Ma Y, Maqsodi B, Papallo A, Peters EH, Poulter K, Ruppel PL, Samaha RR, Shi L, Yang W, Zhang L, Goodsaid FM: Evaluation of DNA microarray results with quantitative gene expression platforms. Nat Biotechnol. 2006, 24 (9): 1115-1122. 10.1038/nbt1236.
Article
CAS
PubMed
Google Scholar
Kriete A, Anderson MK, Love B, Freund J, Caffrey JJ, Young MB, Sendera TJ, Magnuson SR, Braughler JM: Combined histomorphometric and gene-expression profiling applied to toxicology. Genome Biol. 2003, 4 (5): R32-10.1186/gb-2003-4-5-r32.
Article
PubMed Central
PubMed
Google Scholar
Boyce K, Kriete A, Nagatomi S, Kelder B, Coschigano K, Kopchick JJ: Phenotypical enrichment strategies for microarray data analysis applied in a type II diabetes study. Omics. 2005, 9 (3): 251-265. 10.1089/omi.2005.9.251.
Article
CAS
PubMed
Google Scholar
Gaczynska M, Rock KL, Goldberg AL: Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature. 1993, 365 (6443): 264-267. 10.1038/365264a0.
Article
CAS
PubMed
Google Scholar
Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV: Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. J Biol Chem. 2004, 279 (35): 37021-37029. 10.1074/jbc.M404531200.
Article
CAS
PubMed
Google Scholar
Herouy Y, Mellios P, Bandemir E, Dichmann S, Nockowski P, Schopf E, Norgauer J: Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression. J Dermatol Sci. 2001, 25 (3): 198-205. 10.1016/S0923-1811(00)00128-6.
Article
CAS
PubMed
Google Scholar
Puthawala K, Hadjiangelis N, Jacoby SC, Bayongan E, Zhao Z, Yang Z, Devitt ML, Horan GS, Weinreb PH, Lukashev ME, Violette SM, Grant KS, Colarossi C, Formenti SC, Munger JS: Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med. 2008, 177 (1): 82-90. 10.1164/rccm.200706-806OC.
Article
PubMed Central
CAS
PubMed
Google Scholar
Perkins ND: Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007, 8 (1): 49-62. 10.1038/nrm2083.
Article
CAS
PubMed
Google Scholar
Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY: Motif module map reveals enforcement of aging by continual NF-{kappa}B activity. Genes Dev. 2007, 21 (24): 3244-3257. 10.1101/gad.1588507.
Article
PubMed Central
CAS
PubMed
Google Scholar
Adler AS, Kawahara TL, Segal E, Chang HY: Reversal of aging by NFkappaB blockade. Cell Cycle. 2008, 7 (5): 556-559.
Article
CAS
PubMed
Google Scholar
Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S, Hedge P, Bond BC, Jazwinska EC, Barnes MR, Tobin F, Damian-Iordachi V, Greller L, Hurle M, Stubbs AP, Li Z, Valoret EI, Erickson-Miller C, Cass L, Levitt B, Davis HM, Jorkasky DK, Williams WV: Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. DNA Cell Biol. 2005, 24 (7): 410-431. 10.1089/dna.2005.24.410.
Article
CAS
PubMed
Google Scholar
Pahl HL: Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999, 18 (49): 6853-6866. 10.1038/sj.onc.1203239.
Article
CAS
PubMed
Google Scholar
Pilling D, Akbar AN, Girdlestone J, Orteu CH, Borthwick NJ, Amft N, Scheel-Toellner D, Buckley CD, Salmon M: Interferon-beta mediates stromal cell rescue of T cells from apoptosis. Eur J Immunol. 1999, 29 (3): 1041-1050. 10.1002/(SICI)1521-4141(199903)29:03<1041::AID-IMMU1041>3.0.CO;2-#.
Article
CAS
PubMed
Google Scholar
Janssens S, Tschopp J: Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ. 2006, 13 (5): 773-784. 10.1038/sj.cdd.4401843.
Article
CAS
PubMed
Google Scholar
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004, 429 (6990): 417-423. 10.1038/nature02517.
Article
CAS
PubMed
Google Scholar
Lim KS, Jeyaseelan K, Whiteman M, Jenner A, Halliwell B: Oxidative damage in mitochondrial DNA is not extensive. Ann N Y Acad Sci. 2005, 1042: 210-220. 10.1196/annals.1338.023.
Article
CAS
PubMed
Google Scholar
Khrapko K, Kraytsberg Y, de Grey AD, Vijg J, Schon EA: Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?. Aging Cell. 2006, 5 (3): 279-282. 10.1111/j.1474-9726.2006.00209.x.
Article
CAS
PubMed
Google Scholar
Kujoth GC, Bradshaw PC, Haroon S, Prolla TA: The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet. 2007, 3 (2): e24-10.1371/journal.pgen.0030024.
Article
PubMed Central
PubMed
Google Scholar
Maziere C, Auclair M, Djavaheri-Mergny M, Packer L, Maziere JC: Oxidized low density lipoprotein induces activation of the transcription factor NF kappa B in fibroblasts, endothelial and smooth muscle cells. Biochem Mol Biol Int. 1996, 39 (6): 1201-1207.
CAS
PubMed
Google Scholar
Biswas G, Adebanjo OA, Freedman BD, Anandatheerthavarada HK, Vijayasarathy C, Zaidi M, Kotlikoff M, Avadhani NG: Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. Embo J. 1999, 18 (3): 522-533. 10.1093/emboj/18.3.522.
Article
PubMed Central
CAS
PubMed
Google Scholar
Biswas G, Anandatheerthavarada HK, Zaidi M, Avadhani NG: Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol. 2003, 161 (3): 507-519. 10.1083/jcb.200211104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Meng F, Liu L, Chin PC, D'Mello SR: Akt is a downstream target of NF-kappa B. J Biol Chem. 2002, 277 (33): 29674-29680. 10.1074/jbc.M112464200.
Article
CAS
PubMed
Google Scholar
Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, Huang P: Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol. 2006, 175 (6): 913-923. 10.1083/jcb.200512100.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chung HY, Kim HJ, Kim JW, Yu BP: The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann N Y Acad Sci. 2001, 928: 327-335.
Article
CAS
PubMed
Google Scholar
Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA: Gene regulation and DNA damage in the ageing human brain. Nature. 2004, 429 (6994): 883-891. 10.1038/nature02661.
Article
CAS
PubMed
Google Scholar
Aoshiba K, Nagai A: Chronic lung inflammation in aging mice. FEBS Lett. 2007, 581 (18): 3512-3516. 10.1016/j.febslet.2007.06.075.
Article
CAS
PubMed
Google Scholar
Kelder B, Boyce K, Kriete A, Clark R, Berryman DE, Nagatomi S, List EO, Braughler M, Kopchick JJ: CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis. Comp Hepatol. 2007, 6: 4-10.1186/1476-5926-6-4.
Article
PubMed Central
PubMed
Google Scholar
Rodwell GE, Sonu R, Zahn JM, Lund J, Wilhelmy J, Wang L, Xiao W, Mindrinos M, Crane E, Segal E, Myers BD, Brooks JD, Davis RW, Higgins J, Owen AB, Kim SK: A transcriptional profile of aging in the human kidney. PLoS Biol. 2004, 2 (12): e427-10.1371/journal.pbio.0020427.
Article
PubMed Central
PubMed
Google Scholar
Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G: Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. Faseb J. 2003, 17 (9): 1183-1185.
CAS
PubMed
Google Scholar
Helenius M, Hanninen M, Lehtinen SK, Salminen A: Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J Mol Cell Cardiol. 1996, 28 (3): 487-498. 10.1006/jmcc.1996.0045.
Article
CAS
PubMed
Google Scholar
Korhonen P, Helenius M, Salminen A: Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci Lett. 1997, 225 (1): 61-64. 10.1016/S0304-3940(97)00190-0.
Article
CAS
PubMed
Google Scholar
Kim HJ, Kim KW, Yu BP, Chung HY: The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic Biol Med. 2000, 28 (5): 683-692. 10.1016/S0891-5849(99)00274-9.
Article
CAS
PubMed
Google Scholar
Bar-Shai M, Carmeli E, Reznick AZ: The role of NF-kappaB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health. Ann N Y Acad Sci. 2005, 1057: 431-447. 10.1196/annals.1356.034.
Article
CAS
PubMed
Google Scholar
Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR: Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res. 2007, 100 (11): 1659-1666. 10.1161/01.RES.0000269183.13937.e8.
Article
CAS
PubMed
Google Scholar