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  1. Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced...

    Authors: Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu, Szu-Yu Pan, Feng-Jung Yang, Te-Tien Ting, Ju-Ying Jiang, Yu-Sen Peng and Yi-Fang Chuang

    Citation: Immunity & Ageing 2020 17:31

    Content type: Research

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  2. With the ageing of the world population, osteoporosis has become a problem affecting quality of life. According to the traditional view, the causes of osteoporosis mainly include endocrine disorders, metabolic...

    Authors: Lei Zhu, Fei Hua, Wenge Ding, Kai Ding, Yige Zhang and Chenyang Xu

    Citation: Immunity & Ageing 2020 17:30

    Content type: Review

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  3. It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is limited and inconsistent, especially for the elderly ...

    Authors: Jing Guo, Nicole Schupf, Richard P. Mayeux and Yian Gu

    Citation: Immunity & Ageing 2020 17:29

    Content type: Research

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  4. The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circu...

    Authors: Aaron Arvey, Michael Rowe, Joseph Barten Legutki, Gang An, Anantha Gollapudi, Anna Lei, Bill Colston, Chaim Putterman, David Smith, Janelle Stiles, Theodore Tarasow and Preveen Ramamoorthy

    Citation: Immunity & Ageing 2020 17:28

    Content type: Research

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  5. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells developing from myeloid progenitors, which are enriched in pathological conditions such as cancer, and are kno...

    Authors: Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri and Susanna Mandruzzato

    Citation: Immunity & Ageing 2020 17:27

    Content type: Short report

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  6. T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major...

    Authors: Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati and Timothy A. Chan

    Citation: Immunity & Ageing 2020 17:26

    Content type: Short report

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  7. Altered monocyte NF-κB signaling is a possible cause of inflammaging and driver of aging, however, evidence from human aging studies is sparse. We assessed monocyte NF-κB signaling across different aging traje...

    Authors: Juliette Tavenier, Line Jee Hartmann Rasmussen, Morten Baltzer Houlind, Aino Leegaard Andersen, Inge Panum, Ove Andersen, Janne Petersen, Anne Langkilde and Jan O. Nehlin

    Citation: Immunity & Ageing 2020 17:25

    Content type: Research

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  8. Immunologic aging leads to immune dysfunction, significantly reducing the quality of life of the elderly. Aged-related defects in early hematopoiesis result in reduced lymphoid cell development, functionally d...

    Authors: Michelle L. Ratliff, Joshua Garton, Judith A. James and Carol F. Webb

    Citation: Immunity & Ageing 2020 17:24

    Content type: Research

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  9. A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who recover from the hyperinflammatory state characterizing COVI...

    Authors: Arsun Bektas, Shepherd H. Schurman, Claudio Franceschi and Luigi Ferrucci

    Citation: Immunity & Ageing 2020 17:23

    Content type: Opinion

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  10. The SARS-CoV-2 infection has widely spread to become the greatest public health challenge to date, the COVID-19 pandemic. Different fatality rates among countries are probably due to non-standardized records b...

    Authors: Aurora Jurado, María C. Martín, Cristina Abad-Molina, Antonio Orduña, Alba Martínez, Esther Ocaña, Oscar Yarce, Ana M. Navas, Antonio Trujillo, Luis Fernández, Esther Vergara, Beatriz Rodríguez, Bibiana Quirant, Eva Martínez-Cáceres, Manuel Hernández, Janire Perurena-Prieto…

    Citation: Immunity & Ageing 2020 17:22

    Content type: Research

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  11. With advancing age, the composition of leukocyte subpopulations in peripheral blood is known to change, but how this change differs between men and women and how it relates to frailty is poorly understood. Our...

    Authors: Leonard Daniël Samson, A. Mieke H. Boots, José A. Ferreira, H. Susan J. Picavet, Lia G. H. de Rond, Mary-lène de Zeeuw-Brouwer, W. M. Monique Verschuren, Anne-Marie Buisman and Peter Engelfriet

    Citation: Immunity & Ageing 2020 17:20

    Content type: Research

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  12. There is increasing recognition of the significance of chronic, low-level inflammation in older adults, or “inflammaging.” Innate immune responses and host-bacterial interactions are recognized as key factors ...

    Authors: David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield and Moon H. Nahm

    Citation: Immunity & Ageing 2020 17:18

    Content type: Research

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  13. The standard frontline therapy for patients with diffuse large B cell lymphoma (DLBCL) is R-CHOP. However, patients older than 80 years are excluded from clinical trials. The importance of rituximab and anthra...

    Authors: Huai-Hsuan Huang, Bor-Sheng Ko, Ho-Min Chen, Li-Ju Chen, Chen-Yu Wang and Fei-Yuan Hsiao

    Citation: Immunity & Ageing 2020 17:17

    Content type: Research

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  14. Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, ...

    Authors: Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez and Judith Campisi

    Citation: Immunity & Ageing 2020 17:16

    Content type: Review

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  15. Obesity has been associated with chronic inflammation and oxidative stress. Both conditions play a determinant role in the pathogenesis of age-related diseases, such as immunosenescence. Adipose tissue can mod...

    Authors: Luca Pangrazzi, Erin Naismith, Carina Miggitsch, Jose’ Antonio Carmona Arana, Michael Keller, Beatrix Grubeck-Loebenstein and Birgit Weinberger

    Citation: Immunity & Ageing 2020 17:15

    Content type: Research

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  16. While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it has a more devastating impact on the hea...

    Authors: Eladio J. Márquez, Jennifer Trowbridge, George A. Kuchel, Jacques Banchereau and Duygu Ucar

    Citation: Immunity & Ageing 2020 17:13

    Content type: Review

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  17. Exercise can improve immune health and is beneficial for physical function in patients with rheumatoid arthritis (RA), but the immunological mechanisms are largely unknown. We evaluated the effect of moderate-...

    Authors: Sofia E. M. Andersson, Elvira Lange, Daniel Kucharski, Sara Svedlund, Karin Önnheim, Maria Bergquist, Elisabet Josefsson, Janet M. Lord, Inga-Lill Mårtensson, Kaisa Mannerkorpi and Inger Gjertsson

    Citation: Immunity & Ageing 2020 17:12

    Content type: Research

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  18. The human genome contains remnants of ancient retroviral infections called human endogenous retroviruses (HERV). Their expression is often observed in several diseases of autoimmune or inflammatory nature. How...

    Authors: Arttu Autio, Tapio Nevalainen, Binisha H. Mishra, Marja Jylhä, Heini Flinck and Mikko Hurme

    Citation: Immunity & Ageing 2020 17:11

    Content type: Research

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  19. Despite widespread influenza vaccination programs, influenza remains a major cause of morbidity and mortality in older adults. Age-related changes in multiple aspects of the adaptive immune response to influen...

    Authors: Janet E. McElhaney, Chris P. Verschoor, Melissa K. Andrew, Laura Haynes, George A. Kuchel and Graham Pawelec

    Citation: Immunity & Ageing 2020 17:10

    Content type: Review

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  20. Reduced response to hepatitis B vaccines is associated with aging, confounding and comorbid conditions, as well as inadvertent subcutaneous (SC) inoculation. We hypothesized that the antibody and T cell-mediat...

    Authors: Robert Edelman, Meagan E. Deming, Franklin R. Toapanta, Mark D. Heuser, Lisa Chrisley, Robin S. Barnes, Steven S. Wasserman, William C. Blackwelder, Barry S. Handwerger, Marcela Pasetti, Khan M. Siddiqui and Marcelo B. Sztein

    Citation: Immunity & Ageing 2020 17:9

    Content type: Research

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  21. Obesity is a risk factor for several aging-related diseases such as type 2 diabetes, cardiovascular disease, and cancer. Especially, cardiovascular disease is triggered by obesity by inducing vascular senescen...

    Authors: Lutz Hamann, Malgorzata Szwed, Malgorzata Mossakowska, Jerzy Chudek and Monika Puzianowska-Kuznicka

    Citation: Immunity & Ageing 2020 17:7

    Content type: Short report

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  22. “Inflammaging” is a coined term that combines the processes of inflammation (within the normal range) and aging, since chronic, low-grade, systemic inflammation emerges with increasing age. Unlike high-level i...

    Authors: Jessica Fischer, Didier Hans, Olivier Lamy, Pedro Marques-Vidal, Peter Vollenweider and Bérengère Aubry-Rozier

    Citation: Immunity & Ageing 2020 17:5

    Content type: Research

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  23. End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assess...

    Authors: Michiel G. H. Betjes, Anton W. Langerak, Mariska Klepper and Nicolle H. R. Litjens

    Citation: Immunity & Ageing 2020 17:4

    Content type: Research

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  24. The number of aging cancer patients has increased continuously and will do so further in the future. The immune system of elderly people experiences critical changes over the time. Therefore, tumor-induced cha...

    Authors: S. S. Jeske, P. J. Schuler, J. Doescher, M. N. Theodoraki, S. Laban, C. Brunner, T. K. Hoffmann and M. C. Wigand

    Citation: Immunity & Ageing 2020 17:3

    Content type: Research

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  25. Cytokines are signaling molecules operating within complex cascade patterns and having exceptional modulatory functions. They impact various physiological processes such as neuroendocrine and metabolic interac...

    Authors: Svetlana Di Benedetto, Ludmila Müller, Stefanie Rauskolb, Michael Sendtner, Timo Deutschbein, Graham Pawelec and Viktor Müller

    Citation: Immunity & Ageing 2019 16:31

    Content type: Research

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  26. Inflammatory markers, such as high sensitivity C-reactive protein (hs-CRP), and cognitive impairment (CI) are associated with mortality; CRP is related to the deterioration of CI. However, it is still unknown ...

    Authors: Chen Chen, Yingchun Liu, Zhaojin Cao, Zhaoxue Yin, Feng Zhao, Yuebin Lv, Zuyun Liu, Chen Mao, Shixun Song, Ling Liu, Yingli Qu, Saisai Ji, Jun Duan, Jiaonan Wang, Virginia Byers Kraus, Yi Zeng…

    Citation: Immunity & Ageing 2019 16:30

    Content type: Research

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  27. Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human sy...

    Authors: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Sandra Ergueta, Eduardo Martín, Cristina Municio, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado and José L. Pablos

    Citation: Immunity & Ageing 2019 16:29

    Content type: Research

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  28. The association of high-sensitivity C-reactive protein (hsCRP) with mortality is controversial. We aimed to investigate the associations of hsCRP concentrations with the risks of all-cause and cause-specific m...

    Authors: Zhi-Hao Li, Wen-Fang Zhong, Yue-Bin Lv, Virginia Byers Kraus, Xiang Gao, Pei-Liang Chen, Qing-Mei Huang, Jin-Dong Ni, Xiao-Ming Shi, Chen Mao and Xian-Bo Wu

    Citation: Immunity & Ageing 2019 16:28

    Content type: Research

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  29. Administered intramuscularly (IM), plant-derived, virus-like-particle (VLP) vaccines based on the influenza hemagglutinin (HA) protein elicit both humoral and cellular responses that can protect aged mice from...

    Authors: Breanna Hodgins, Stephane Pillet, Nathalie Landry and Brian J. Ward

    Citation: Immunity & Ageing 2019 16:27

    Content type: Research

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  30. While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults,...

    Authors: S. Paghera, E. Quiros-Roldan, A. Sottini, M. Properzi, F. Castelli and L. Imberti

    Citation: Immunity & Ageing 2019 16:26

    Content type: Research

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  31. The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine res...

    Authors: Stephen N. Crooke, Inna G. Ovsyannikova, Gregory A. Poland and Richard B. Kennedy

    Citation: Immunity & Ageing 2019 16:25

    Content type: Review

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  32. T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage an...

    Authors: Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li and Ling Xu

    Citation: Immunity & Ageing 2019 16:24

    Content type: Short report

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  33. Influenza virus infection causes significant morbidity and mortality worldwide. Humans fail to make a universally protective memory response to influenza A because of high mutation rates in the immune-dominant...

    Authors: Lynn Bimler, Amber Y. Song, Duy T. Le, Ashleigh Murphy Schafer and Silke Paust

    Citation: Immunity & Ageing 2019 16:23

    Content type: Research

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  34. Aging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologi...

    Authors: Alice F. Muggen, Madelon de Jong, Ingrid L. M. Wolvers-Tettero, Martine J. Kallemeijn, Cristina Teodósio, Nikos Darzentas, Ralph Stadhouders, Hanna IJspeert, Mirjam van der Burg, Wilfred FJ van IJcken, Jan A. N. Verhaar, Wayel H. Abdulahad, Elisabeth Brouwer, Annemieke M. H. Boots, Rudi W. Hendriks, Jacques J. M. van Dongen…

    Citation: Immunity & Ageing 2019 16:22

    Content type: Research

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  35. Antigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations in the BM changes with ag...

    Authors: Erin Naismith, Luca Pangrazzi, Marco Grasse, Michael Keller, Carina Miggitsch, Birgit Weinberger, Klemens Trieb and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2019 16:21

    Content type: Research

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  36. Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clini...

    Authors: Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Charlotte Liisborg, Helle Bach Søndergaard, Finn Sellebjerg and Torben Lykke Sørensen

    Citation: Immunity & Ageing 2019 16:20

    Content type: Research

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  37. Immunosenescence, i.e. the aging-associated decline of the capacity of the immune system, is characterized by several distinct changes in the number and functions of the immune cells. In the case of B cells, t...

    Authors: Tapio Nevalainen, Arttu Autio, Laura Kummola, Tanja Salomaa, Ilkka Junttila, Marja Jylhä and Mikko Hurme

    Citation: Immunity & Ageing 2019 16:19

    Content type: Research

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  38. Systemic infection is associated with long-term cognitive deficits and functional decline. In this study we hypothesized that severe systemic inflammation leads to a neuroinflammatory response that is characte...

    Authors: D. Westhoff, J. Y. Engelen-Lee, I. C. M. Hoogland, E. M. A. Aronica, D. J. van Westerloo, D. van de Beek and W. A. van Gool

    Citation: Immunity & Ageing 2019 16:18

    Content type: Research

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  39. Ageing is associated with a decline in immune function termed immunosenescence. This process is characterized amongst others by less naive T-cells and more senescent phenotypes, which have been implicated in t...

    Authors: Hung Cao Dinh, Ivan Bautmans, Ingo Beyer, Oscar Okwudiri Onyema, Keliane Liberman, Liza De Dobbeleer, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Andreas Delaere, Veerle Knoop and Rose Njemini

    Citation: Immunity & Ageing 2019 16:17

    Content type: Research

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  40. Age is a significant risk factor for recurrent urinary tract (rUTI) infections, but the clinical picture is often confused in older patients who also present with asymptomatic bacteriuria (ASB). Yet, how bacte...

    Authors: Lauren K. L. Drage, Wendy Robson, Catherine Mowbray, Ased Ali, John D. Perry, Katherine E. Walton, Christopher Harding, Robert Pickard, Judith Hall and Phillip D. Aldridge

    Citation: Immunity & Ageing 2019 16:16

    Content type: Research

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  41. Cytokines, chemokines, C-reactive proteins (CRP) and ferritin are known inflammatory markers. However, cytokines such as interleukin (IL-1β), (IL-6) and tumour necrosis factor (TNF-α) have been reported to int...

    Authors: Bolaji Lilian Ilesanmi-Oyelere, Linda Schollum, Barbara Kuhn-Sherlock, Michelle McConnell, Sonya Mros, Jane Coad, Nicole C. Roy and Marlena Cathorina Kruger

    Citation: Immunity & Ageing 2019 16:15

    Content type: Research

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  42. Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeo...

    Authors: I. Herrero-Fernández, I. Rosado-Sánchez, A. I. Álvarez-Ríos, M. I. Galvá, M. De Luna-Romero, S. Sanbonmatsu-Gámez, M. Pérez-Ruiz, J. M. Navarro-Marí, A. Carrillo-Vico, B. Sánchez, R. Ramos, J. Cañizares, M. Leal and Y. M. Pacheco

    Citation: Immunity & Ageing 2019 16:14

    Content type: Research

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