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  1. With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers of elderly patients were undergoing allogeneic HSCT and elderly patients with hematologic malignancies coul...

    Authors: Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen and Xiaoyu Zhou
    Citation: Immunity & Ageing 2024 21:15
  2. The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of agin...

    Authors: Ruikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang and Peng Yu
    Citation: Immunity & Ageing 2024 21:14
  3. Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging. It has...

    Authors: Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery and Hamid Zand
    Citation: Immunity & Ageing 2024 21:13
  4. In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, w...

    Authors: Yuwei Zhang, Lianxiang Zhao, Jinzhong Zhang, Xiaomei Zhang, Shanshan Han, Qingshuai Sun, Mingxiao Yao, Bo Pang, Qing Duan and Xiaolin Jiang
    Citation: Immunity & Ageing 2024 21:11
  5. Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian tissue homeostasis and immune surveillance. However, the impact of agi...

    Authors: Hui-Hui Shen, Xin-Yan Zhang, Nan Liu, Yang-Yang Zhang, Hui-Hua Wu, Feng Xie, Wen-Jun Wang and Ming-Qing Li
    Citation: Immunity & Ageing 2024 21:10
  6. Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, ...

    Authors: Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin and Nuning Winaris
    Citation: Immunity & Ageing 2024 21:9
  7. The Disposable Soma Theory of aging suggests a trade-off between energy allocation for growth, reproduction and somatic maintenance, including immunity. While trade-offs between reproduction and immunity are w...

    Authors: Agathe Crosland, Thierry Rigaud, Charlène Develay and Yannick Moret
    Citation: Immunity & Ageing 2024 21:7
  8. The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convale...

    Authors: Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling…
    Citation: Immunity & Ageing 2024 21:6
  9. Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, ...

    Authors: Jianjie Lv, Chun Zhang, Xiuxing Liu, Chenyang Gu, Yidan Liu, Yuehan Gao, Zhaohao Huang, Qi Jiang, Binyao Chen, Daquan He, Tianfu Wang, Zhuping Xu and Wenru Su
    Citation: Immunity & Ageing 2024 21:3
  10. Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive d...

    Authors: Cristina Rodriguez-Rodriguez, Natalia González-Mancha, Ane Ochoa-Echeverría, Rosa Liébana and Isabel Merida
    Citation: Immunity & Ageing 2024 21:2
  11. Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence of PD has experienced a significant surg...

    Authors: Bang-rong Wei, Yu-jia Zhao, Yu-feng Cheng, Chun Huang and Feng Zhang
    Citation: Immunity & Ageing 2024 21:1
  12. Coronavirus disease COVID-19 is a heterogeneous condition caused by SARS-CoV-2 infection. Generally, it is characterized by interstitial pneumonia that can lead to impaired gas-exchange, acute respiratory fail...

    Authors: Robertina Giacconi, Patrizia D’Aquila, Maurizio Cardelli, Francesco Piacenza, Elisa Pierpaoli, Giada Sena, Mirko Di Rosa, Anna Rita Bonfigli, Roberta Galeazzi, Antonio Cherubini, Massimiliano Fedecostante, Riccardo Sarzani, Chiara Di Pentima, Piero Giordano, Roberto Antonicelli, Fabrizia Lattanzio…
    Citation: Immunity & Ageing 2023 20:76
  13. Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical studies focusing on analysis of the peripheral blood immune changes underlying ageing,...

    Authors: Xiaomin Fu, Peng Qin, Fanghui Li, Huifang Zhu, Hongqin You, Yong Zhang, Benling Xu, Tiepeng Li, Fang Zhang, Lu Han, Lingdi Zhao, Baozhen Ma, Zibing Wang and Quanli Gao
    Citation: Immunity & Ageing 2023 20:75
  14. Alzheimer’s disease (AD), which is the most common cause of dementia in elderly individuals, is a progressive neurodegenerative disorder. Neuroinflammation, which is an immune response that is activated by gli...

    Authors: Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao and Peichang Wang
    Citation: Immunity & Ageing 2023 20:74
  15. Immunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent T cells also rises with age. T cell senescence and immune response dysfunction can resu...

    Authors: Jia Yang, Hai-Cheng Liu, Jian-Qing Zhang, Jian-Yong Zou, Xin Zhang, Wo-Ming Chen, Yong Gu and Hai Hong
    Citation: Immunity & Ageing 2023 20:73
  16. Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently, therapeutic interventions for oral lichen planus are limited ...

    Authors: Shogo Ijima, Yuki Saito, Sena Yamamoto, Kentaro Nagaoka, Taiki Iwamoto, Arisa Kita, Maki Miyajima, Tsukasa Sato, Akihiro Miyazaki and Takako S. Chikenji
    Citation: Immunity & Ageing 2023 20:72
  17. Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its ge...

    Authors: Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You and Insoo Kang
    Citation: Immunity & Ageing 2023 20:71
  18. Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-related functional degeneration and metabolic diseases. NAD exerts direct and indirect i...

    Authors: Jinghui Liang, Feiling Huang, Zhaoqi Song, Ruiyi Tang, Peng Zhang and Rong Chen
    Citation: Immunity & Ageing 2023 20:70
  19. Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF...

    Authors: Yannick van Sleen, Sudarshan A. Shetty, Marieke van der Heiden, Milou C. A. Venema, Nicolas Gutiérrez-Melo, Erik J. M. Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle and Delphine Sauce
    Citation: Immunity & Ageing 2023 20:68
  20. TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands...

    Authors: Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee and Cheol Hwangbo
    Citation: Immunity & Ageing 2023 20:67
  21. CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to be a diagnostic biomarker for CAD. However, the specific function and detailed mechani...

    Authors: Yahong Fu, Qiaowei Jia, Mengmeng Ren, Hengjie Bie, Xin Zhang, Qian Zhang, Shu He, Chengcheng Li, Hanxiao Zhou, Yanjun Wang, Xiongkang Gan, Zhengxian Tao, Xiumei Chen and Enzhi Jia
    Citation: Immunity & Ageing 2023 20:66
  22. Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to the growth of abnormal blood vessels into the macula, leading to the loss of central visi...

    Authors: Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen and Heping Xu
    Citation: Immunity & Ageing 2023 20:65
  23. The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned long-duration missions, such as the deployment of the Lunar Gateway and pos...

    Authors: Coralie Fonte, Pauline Jacob, Anne Vanet, Stéphanie Ghislin and Jean-Pol Frippiat
    Citation: Immunity & Ageing 2023 20:64
  24. Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remai...

    Authors: Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M. Hatch, Ming Zhang and Li Chen
    Citation: Immunity & Ageing 2023 20:63
  25. About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but may remain at risk of inflammaging, aging, and liver and non-liver dis...

    Authors: Rubén Martín-Escolano, Erick Joan Vidal-Alcántara, Javier Crespo, Pablo Ryan, Luis Miguel Real, Juan Ignacio Lazo-Álvarez, Joaquín Cabezas-González, Juan Macías, María Teresa Arias-Loste, Guillermo Cuevas, Ana Virseda-Berdices, Veronica Briz, Salvador Resino, María Ángeles Jiménez-Sousa and Amanda Fernández-Rodríguez
    Citation: Immunity & Ageing 2023 20:62
  26. Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatric conditions with overlapping phenotypes. Many mechanisms are involved in the aging pr...

    Authors: Tomasz Kmiołek, Gabriela Filipowicz, Diana Bogucka, Anna Wajda, Adam Ejma-Multański, Barbara Stypińska, Ewa Modzelewska, Yana Kaliberda, Marcin Radkowski, Tomasz Targowski, Julia Wrona and Agnieszka Paradowska-Gorycka
    Citation: Immunity & Ageing 2023 20:61
  27. The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized. Genome-wide association studies (GWAS) have recently identified several candidate imm...

    Authors: S. R. Fatemi Langroudi, M. Zeinaly and F. Ajamian
    Citation: Immunity & Ageing 2023 20:59
  28. The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a lifetime exposure to antigens results in structural and functional change...

    Authors: Meng He and Jürgen Borlak
    Citation: Immunity & Ageing 2023 20:58

    The Correction to this article has been published in Immunity & Ageing 2024 21:8

  29. Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related variables potentially underlying the antibody responses to SARS-CoV-2 vaccination in older ...

    Authors: Yunus Kuijpers, H. Susan J. Picavet, Lia de Rond, Mary-lène de Zeeuw-Brouwer, Ryanne Rutkens, Esther Gijsbers, Irene Slits, Peter Engelfriet, Anne-Marie Buisman and W. M. Monique Verschuren
    Citation: Immunity & Ageing 2023 20:57
  30. Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics Lactobacillus paracasei P62 (Lp) and Bifidobacterium bifidum P61 (Bb), which suppressed m...

    Authors: Ji-Su Baek, Yoon-Jung Shin, Xiaoyang Ma, Hee-Seo Park, Yun-Ha Hwang and Dong-Hyun Kim
    Citation: Immunity & Ageing 2023 20:56
  31. Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating...

    Authors: Bernardo Abel Cedeno-Veloz, Lucía Lozano-Vicario, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Enrique Santamaría, Alba Rodríguez-García, Roman Romero-Ortuno, Jaime Mondragon-Rubio, Javier Ruiz-Ruiz, Robinson Ramírez-Vélez, Mikel Izquierdo and Nicolás Martínez-Velilla
    Citation: Immunity & Ageing 2023 20:55
  32. Hip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hidden blood loss and stress due to concealed injury sites could impact the whole osteoimm...

    Authors: Yining Lu, Yang Luo, Qi Zhang, Wei Chen, Ning Zhang, Ling Wang and Yingze Zhang
    Citation: Immunity & Ageing 2023 20:54
  33. Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degeneration (AMD). Understanding the changes that occur in the eye due to aging is importan...

    Authors: Margarete M. Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y. Shu, Shintaro Shirahama, Bruce R. Ksander and Magali Saint-Geniez
    Citation: Immunity & Ageing 2023 20:53

    The Correction to this article has been published in Immunity & Ageing 2023 20:60

  34. Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD). W...

    Authors: Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma and Julian Hellmann-Regen
    Citation: Immunity & Ageing 2023 20:52
  35. Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, wit...

    Authors: L K Grun, R M Maurmann, J N Scholl, M E Fogaça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma and F M Barbé-Tuana
    Citation: Immunity & Ageing 2023 20:51
  36. Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly improved with mice bearing a human immune system, especially in the context o...

    Authors: Joel H. L. Tan, You Yi Hwang, Hui Xian Chin, Min Liu, Sue Yee Tan and Qingfeng Chen
    Citation: Immunity & Ageing 2023 20:49
  37. Primary Sjögren’s syndrome (pSS) is a common chronic systemic autoimmune disorder which primarily affects the exocrine glands. Patients may have extraglandular disease involving multiple organs, including the ...

    Authors: Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang and Haixia Li
    Citation: Immunity & Ageing 2023 20:48
  38. Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship b...

    Authors: Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-Hoffmann, Jakob Linseisen, Christa Meisinger and Dennis Freuer
    Citation: Immunity & Ageing 2023 20:47
  39. Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar...

    Authors: Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino and Luigi Ferrucci
    Citation: Immunity & Ageing 2023 20:46
  40. Fatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is emerging evidence that thymic involution is linked to T cell aging, chronic inflammation ...

    Authors: Mårten Sandstedt, Rosanna W S Chung, Camilla Skoglund, Anna K. Lundberg, Carl Johan Östgren, Jan Ernerudh and Lena Jonasson
    Citation: Immunity & Ageing 2023 20:45
  41. Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the bone marrow and the peripheral tissues or circulation, in particular v...

    Authors: Yixuan Fang, Jiawei Qian, Li Xu, Wen Wei, Wenwen Bu, Suping Zhang, Yaqi Lv, Lei Li, Chen Zhao, Xueqin Gao, Yue Gu, Li Wang, Zixing Chen, Xiao Wang, Ruizhi Zhang, Youjia Xu…
    Citation: Immunity & Ageing 2023 20:44
  42. Women/females report more adverse events (AE) following immunization than men/males for many vaccines, including the influenza and COVID-19 vaccines. This discrepancy is often dismissed as a reporting bias, ye...

    Authors: Janna R. Shapiro, Kumba Seddu, Han-Sol Park, John S. Lee, Patrick S. Creisher, Anna Yin, Patrick Shea, Helen Kuo, Huifen Li, Engle Abrams, Sean X. Leng, Rosemary Morgan and Sabra L. Klein
    Citation: Immunity & Ageing 2023 20:43
  43. Coronavirus disease 2019 (COVID-19) remains a threat to vulnerable populations such as long-term care facility (LTCF) residents, who are often older, severely frail, and have multiple comorbidities. Although a...

    Authors: Tomoyuki Kakugawa, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano, Yusuke Mimura and Kazuto Matsunaga
    Citation: Immunity & Ageing 2023 20:42

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