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  1. Research

    Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration

    Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhe...

    Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi and Torben Lykke Sørensen

    Immunity & Ageing 2017 14:18

    Published on: 27 July 2017

  2. Research

    Influenza vaccine response in community-dwelling German prefrail and frail individuals

    The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest ...

    Jürgen M. Bauer, Antonio De Castro, Nabil Bosco, Celine Romagny, Rebecca Diekmann, Jalil Benyacoub and Karine Vidal

    Immunity & Ageing 2017 14:17

    Published on: 6 July 2017

  3. Research

    Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice

    CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic...

    Jackson Taylor, Lindsay Reynolds, Li Hou, Kurt Lohman, Wei Cui, Stephen Kritchevsky, Charles McCall and Yongmei Liu

    Immunity & Ageing 2017 14:15

    Published on: 20 June 2017

  4. Research

    pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients

    Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (E...

    Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan and Michiel G. H. Betjes

    Immunity & Ageing 2017 14:14

    Published on: 19 June 2017

  5. Research

    Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study

    Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone re...

    Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia and Massimiliano M. Corsi Romanelli

    Immunity & Ageing 2017 14:13

    Published on: 14 June 2017

  6. Research

    Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle

    Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end produ...

    Myeongjoo Son, Wook-Jin Chung, Seyeon Oh, Hyosang Ahn, Chang Hu Choi, Suntaek Hong, Kook Yang Park, Kuk Hui Son and Kyunghee Byun

    Immunity & Ageing 2017 14:12

    Published on: 5 June 2017

  7. Short report

    Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

    Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on ...

    Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral and Jesús Pintor

    Immunity & Ageing 2017 14:11

    Published on: 19 May 2017

  8. Research

    Herpes virus seroepidemiology in the adult Swedish population

    Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex ...

    Jan Olsson, Eloise Kok, Rolf Adolfsson, Hugo Lövheim and Fredrik Elgh

    Immunity & Ageing 2017 14:10

    Published on: 10 May 2017

  9. Research

    Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults

    A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccin...

    Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra and Gregory M. Glenn

    Immunity & Ageing 2017 14:8

    Published on: 12 April 2017

  10. Research

    The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation

    An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...

    Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A. Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli and Valeria Conti

    Immunity & Ageing 2017 14:7

    Published on: 16 March 2017

  11. Research

    CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women

    The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears...

    Silvana Mara Turbino Luz Ribeiro, Laís Roquete Lopes, Guilherme de Paula Costa, Vivian Paulino Figueiredo, Deena Shrestha, Aline Priscila Batista, Roney Luiz de Carvalho Nicolato, Fernando Luiz Pereira de Oliveira, Juliana Assis Silva Gomes and Andre Talvani

    Immunity & Ageing 2017 14:6

    Published on: 11 March 2017

  12. Research

    Changes in peripheral immune cell numbers and functions in octogenarian walkers – an acute exercise study

    Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral ...

    Kornelis S. M. van der Geest, Qi Wang, Thijs M. H. Eijsvogels, Hans J. P. Koenen, Irma Joosten, Elisabeth Brouwer, Maria T. E. Hopman, Joannes F. M. Jacobs and Annemieke M. H. Boots

    Immunity & Ageing 2017 14:5

    Published on: 22 February 2017

  13. Research

    Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals

    Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytok...

    Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M. Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira…

    Immunity & Ageing 2017 14:2

    Published on: 23 January 2017

  14. Research

    Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors

    NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression...

    Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

    Immunity & Ageing 2017 14:3

    Published on: 23 January 2017

  15. Research

    A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

    Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Conseq...

    E. Vianello, E. Dozio, A. Barassi, G. Sammarco, L. Tacchini, M. M. Marrocco-Trischitta, S. Trimarchi and M. M. Corsi Romanelli

    Immunity & Ageing 2017 14:1

    Published on: 5 January 2017

  16. Research

    Frailty has a stronger association with inflammation than age in older veterans

    Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the ...

    P. Van Epps, D. Oswald, P. A. Higgins, T. R. Hornick, H. Aung, R. E. Banks, B. M. Wilson, C. Burant, S. Gravenstein and D. H. Canaday

    Immunity & Ageing 2016 13:27

    Published on: 19 October 2016

    The Erratum to this article has been published in Immunity & Ageing 2017 14:4

  17. Short report

    Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults

    We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals....

    Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein and Birgit Weinberger

    Immunity & Ageing 2016 13:26

    Published on: 5 September 2016

  18. Review

    The inflammatory protein Pentraxin 3 in cardiovascular disease

    The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate...

    Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A. Puca and Carmine Vecchione

    Immunity & Ageing 2016 13:25

    Published on: 24 August 2016

  19. Research

    Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

    Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...

    Yun Lin, Jiewan Kim, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci and Nan-ping Weng

    Immunity & Ageing 2016 13:24

    Published on: 18 August 2016

  20. Research

    Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

    There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have lon...

    A. Trovato, R. Siracusa, R. Di Paola, M. Scuto, M. L. Ontario, Ornella Bua, Paola Di Mauro, M. A. Toscano, C. C. T. Petralia, L. Maiolino, A. Serra, S. Cuzzocrea and Vittorio Calabrese

    Immunity & Ageing 2016 13:23

    Published on: 9 July 2016

  21. Research

    Elastic band resistance training influences transforming growth factor-ß receptor I mRNA expression in peripheral mononuclear cells of institutionalised older adults: the Vienna Active Ageing Study (VAAS)

    Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with vari...

    Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Bernhard Franzke, Thomas Wolf, Eva-Maria Strasser, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner and Barbara Wessner

    Immunity & Ageing 2016 13:22

    Published on: 30 June 2016

  22. Research

    Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

    In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and ol...

    Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek and Malgorzata Mossakowska

    Immunity & Ageing 2016 13:21

    Published on: 3 June 2016

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