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  1. Content type: Research

    The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patie...

    Authors: Judith Lechner, Mei Chen, Ruth E. Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy and Heping Xu

    Citation: Immunity & Ageing 2016 13:4

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  2. Content type: Research

    Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral T cell renewal during human life. These processes are expected to be accelerate...

    Authors: Manuela Zlamy, Giovanni Almanzar, Walther Parson, Christian Schmidt, Johannes Leierer, Birgit Weinberger, Verena Jeller, Karin Unsinn, Matthias Eyrich, Reinhard Würzner and Martina Prelog

    Citation: Immunity & Ageing 2016 13:3

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  3. Content type: Research

    Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the wi...

    Authors: Susanna Esposito, Daniela Mari, Luigi Bergamaschini, Annalisa Orenti, Leonardo Terranova, Luca Ruggiero, Valentina Ierardi, Monia Gambino, Francesco Della Croce and Nicola Principi

    Citation: Immunity & Ageing 2016 13:2

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  4. Content type: Research

    Cytomegalovirus (CMV) is a highly prevalent herpesvirus, which maintains lifelong latency and places a significant burden on host immunity. Infection is associated with increased rates of vascular disease and ...

    Authors: Helen M. Parry, Jianmin Zuo, Guido Frumento, Nikhil Mirajkar, Charlotte Inman, Emma Edwards, Mike Griffiths, Guy Pratt and Paul Moss

    Citation: Immunity & Ageing 2016 13:1

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  5. Content type: Research

    People that reach extreme ages (Long-Living Individuals, LLIs) are object of intense investigation for increase/decrease of genetic variant frequencies, genetic methylation levels, protein abundance in serum a...

    Authors: Francesco Villa, Alberto Malovini, Albino Carrizzo, Chiara C. Spinelli, Anna Ferrario, Anna Maciąg, Michele Madonna, Riccardo Bellazzi, Luciano Milanesi, Carmine Vecchione and Annibale A. Puca

    Citation: Immunity & Ageing 2015 12:27

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  6. Content type: Research

    End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens....

    Authors: Ling Huang, Anton W. Langerak, Ingrid L. M. Wolvers-Tettero, Ruud W. J. Meijers, Carla C. Baan, Nicolle H. R. Litjens and Michiel G. H. Betjes

    Citation: Immunity & Ageing 2015 12:28

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  7. Content type: Research

    Aging and latent infection with Cytomegalovirus (CMV) are thought to be major factors driving the immune system towards immunosenescence, primarily characterized by reduced amounts of naïve T-cells and increas...

    Authors: Kilian Wistuba-Hamprecht, Karin Haehnel, Nicole Janssen, Ilja Demuth and Graham Pawelec

    Citation: Immunity & Ageing 2015 12:25

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  8. Content type: Research

    Bacillus probiotics health benefits have been until now quite poorly studied in the elderly population. This study aimed to assess the effects of Bacillus subtilis CU1 consumption on i...

    Authors: Marie Lefevre, Silvia M. Racedo, Gabrielle Ripert, Béatrice Housez, Murielle Cazaubiel, Corinne Maudet, Peter Jüsten, Philippe Marteau and Maria C. Urdaci

    Citation: Immunity & Ageing 2015 12:24

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  9. Content type: Short report

    Degenerative granular structures appear progressively with age in the hippocampus of most mouse strains. We recently reported that these granules contain a neo-epitope that is recognised by IgM antibodies pres...

    Authors: Gemma Manich, Elisabet Augé, Itsaso Cabezón, Mercè Pallàs, Jordi Vilaplana and Carme Pelegrí

    Citation: Immunity & Ageing 2015 12:23

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  10. Content type: Research

    Both aging and obesity have been recognized widely as health conditions that profoundly affect individuals, families and the society. Aged and obese people often report altered pain responses while underlying ...

    Authors: SeungHwan Lee, YaSi Wu, Xiang Qun Shi and Ji Zhang

    Citation: Immunity & Ageing 2015 12:22

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  11. Content type: Research

    The level of expression of the interleukin 7 receptor (IL7R) gene in blood has recently been found to be associated with familial longevity and healthy ageing. IL7R is crucial for T cell development and important...

    Authors: Willemijn M. Passtoors, Erik B. van den Akker, Joris Deelen, Andrea B. Maier, Ruud van der Breggen, Rick Jansen, Stella Trompet, Diana van Heemst, Evelyna Derhovanessian, Graham Pawelec, Gert-Jan B. van Ommen, P. Eline Slagboom and Marian Beekman

    Citation: Immunity & Ageing 2015 12:21

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  12. Content type: Review

    Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneratio...

    Authors: Sandro Dattilo, Cesare Mancuso, Guido Koverech, Paola Di Mauro, Maria Laura Ontario, Cateno Concetto Petralia, Antonino Petralia, Luigi Maiolino, Agostino Serra, Edward J. Calabrese and Vittorio Calabrese

    Citation: Immunity & Ageing 2015 12:20

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  13. Content type: Research

    The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory d...

    Authors: Tarja Kunnas, Kirsi Määttä and Seppo T. Nikkari

    Citation: Immunity & Ageing 2015 12:19

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  14. Content type: Research

    Thymic involution is thought to be an important factor of age related immunodeficiency. Understanding the molecular mechanisms of human thymic senescence may lead to the discovery of novel therapeutic approach...

    Authors: Maria Danielma dos Santos Reis, Krisztian Csomos, Luciene Paschoal Braga Dias, Zsolt Prodan, Tamas Szerafin, Wilson Savino and Laszlo Takacs

    Citation: Immunity & Ageing 2015 12:18

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  15. Content type: Research

    Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data,...

    Authors: Yu-hong Wang, Xu-hui Yu, Shan-shun Luo and Hui Han

    Citation: Immunity & Ageing 2015 12:17

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  16. Content type: Research

    Aging influences immune response and susceptibility to EAE in a strain specific manner. The study was designed to examine influence of aging on EAE induction in Albino Oxford (AO) rats.

    Authors: Zorica Stojić-Vukanić, Mirjana Nacka-Aleksić, Ivan Pilipović, Ivana Vujnović, Veljko Blagojević, Duško Kosec, Mirjana Dimitrijević and Gordana Leposavić

    Citation: Immunity & Ageing 2015 12:16

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  17. Content type: Short report

    Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-i...

    Authors: Xiaoyu Wu, Maani Hakimi, Markus Wortmann, Jian Zhang, Dittmar Böckler and Susanne Dihlmann

    Citation: Immunity & Ageing 2015 12:15

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  18. Content type: Research

    Most HIV-infected persons are cytomegalovirus (CMV) seropositive and retain latent virus that can be reactivated by immune activation. Their T cell populations express markers reflecting a late stage of differ...

    Authors: Jacquita S. Affandi, Jacinta Montgomery, Samantha J. Brunt, David Nolan and Patricia Price

    Citation: Immunity & Ageing 2015 12:14

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  19. Content type: Erratum

    Authors: Maohua Zhou, Ruqiong Zou, Huiquan Gan, Zhimei Liang, Fujun Li, Ting Lin, Yanfei Luo, Xiaoming Cai, Fang He and Erxia Shen

    Citation: Immunity & Ageing 2015 12:13

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    The original article was published in Immunity & Ageing 2014 11:12

  20. Content type: Research

    The immune system undergoes several alterations of innate and adaptive immunity during ageing. The main features of the aged immune system are a reduced diversity of T cell receptors and a reduced activity of ...

    Authors: Georg Pongratz, Torsten Lowin, Robert Kob, Roland Buettner, Thomas Bertsch and L. Cornelius Bollheimer

    Citation: Immunity & Ageing 2015 12:12

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  21. Content type: Research

    Rotenone inhibits the electron transfer from complex I to ubiquinone, in this way interfering with the electron transport chain in mitochondria. This chain of events induces increased levels of intracellular r...

    Authors: Shiva Marthandan, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich and Stephan Diekmann

    Citation: Immunity & Ageing 2015 12:11

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  22. Content type: Research

    HIV-infected patients could exhibit accelerated ageing, since age-associated complications like sarcopenia; increased inflammation; lipodystrophy with loss of subcutaneous adipose tissue and/or gain of viscera...

    Authors: Anne Langkilde, Janne Petersen, Jens Henrik Henriksen, Frank Krieger Jensen, Jan Gerstoft, Jesper Eugen-Olsen and Ove Andersen

    Citation: Immunity & Ageing 2015 12:9

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  23. Content type: Research

    Determining the prerequisites for healthy aging is a major task in the modern world characterized by a longer lifespan of the individuals. Besides lifestyle and environmental influences genetic factors are inv...

    Authors: Lutz Hamann, Juozas Kupcinskas, Luis C. Berrocal Almanza, Jurgita Skieceviciene, Andre Franke, Ute Nöthlings and Ralf R. Schumann

    Citation: Immunity & Ageing 2015 12:7

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    The Erratum to this article has been published in Immunity & Ageing 2015 12:10

  24. Content type: Short report

    Ineffective induction of T cell mediated immunity in older individuals remains a persistent challenge for vaccine development. Thus, there is a need for more efficient and sophisticated adjuvants that will com...

    Authors: Gee Jun Tye, Kyriaki Ioannou, Eunice Amofah, Ruby Quartey-Papafio, Samantha J. Westrop, Pramila Krishnamurthy, Alistair Noble, Phillip M. Harrison, Karin M.L. Gaensler, Linda D. Barber and Farzin Farzaneh

    Citation: Immunity & Ageing 2015 12:6

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  25. Content type: Research

    Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bon...

    Authors: Fanny Pojero, Alessandra Casuccio, Francesco Di Bassiano, Francesco Gervasi, Giuseppina Colonna Romano and Calogero Caruso

    Citation: Immunity & Ageing 2015 12:5

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  26. Content type: Research

    Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism caus...

    Authors: Simon Schneider, Werner Koch, Petra Hoppmann, Romy Ubrich, Stephan Kemmner, Eva Steinlechner, Uwe Heemann, Karl-Ludwig Laugwitz, Adnan Kastrati and Marcus Baumann

    Citation: Immunity & Ageing 2015 12:4

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  27. Content type: Research

    The worldwide increase in life expectancy has been associated with an increase in age-related morbidities. The underlying mechanisms resulting in immunosenescence are only incompletely understood. Chronic vira...

    Authors: Kristie L Oxford, Myra Grace A dela Pena-Ponce, Kara Jensen, Meghan K Eberhardt, Abigail Spinner, Koen KA Van Rompay, Joseph Rigdon, Katie R Mollan, VV Krishnan, Michael G Hudgens, Peter A Barry and Kristina De Paris

    Citation: Immunity & Ageing 2015 12:3

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  28. Content type: Research

    Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to pathogenesis and pathology of vascular-based neurodegenerative disorders such as Alzheimer’s disease. We recently reported in wild-typ...

    Authors: Mina Elahy, Connie Jackaman, John CL Mamo, Virginie Lam, Satvinder S Dhaliwal, Corey Giles, Delia Nelson and Ryusuke Takechi

    Citation: Immunity & Ageing 2015 12:2

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  29. Content type: Research

    We originally cloned and identified murine Zizimin2 (Ziz2, Dock11) as a guanine nucleotide exchange factor (GEF) for Cdc42 and demonstrated that it activated the formation of filopodia. Since its expression pa...

    Authors: Takenori Matsuda, Shougo Yanase, Akinori Takaoka and Mitsuo Maruyama

    Citation: Immunity & Ageing 2015 12:1

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  30. Content type: Short report

    Cardiotrophin-1 (CT-1), a cytokine produced by cardiomyocytes and non-cardiomyocytes in conditions of stress, can be used as a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients...

    Authors: Monica Gioia Marazzi, Emanuela Galliera, Elena Vianello, Elena Dozio, Andrea Stella, Guido Tettamanti, Lorenza Tacchini and Massimiliano M Corsi Romanelli

    Citation: Immunity & Ageing 2014 11:27

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  31. Content type: Research

    Ageing is accompanied by reduced immunity, termed immunesenescence. The immune system does not act in isolation and is sensitive to both psychological and physical stress. Hip fracture is a common physical str...

    Authors: Niharika Arora Duggal, Jane Upton, Anna C Phillips, Peter Hampson and Janet M Lord

    Citation: Immunity & Ageing 2014 11:25

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  32. Content type: Short report

    Tuberculosis, the disease due to Mycobacterium tuberculosis, is an important cause of morbidity and mortality in the elderly. Use of mouse models may accelerate insight into the disease and tests of therapies sin...

    Authors: David E Harrison, Clinton M Astle, M Khalid Khan Niazi, Samuel Major and Gillian L Beamer

    Citation: Immunity & Ageing 2014 11:24

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  33. Content type: Research

    Despite significant medical progress and improved treatment, surgical procedures of proximal femur fractures in older patients are still associated with a high postoperative complication and mortality rate. Re...

    Authors: Helen Vester, Markus S Huber-Lang, Qerim Kida, Alexander Scola, Martijn van Griensven, Florian Gebhard, Andreas K Nüssler and Mario Perl

    Citation: Immunity & Ageing 2014 11:20

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  34. Content type: Review

    Alzheimer’s disease (AD) is a complex disease resulting in neurodegeneration and cognitive impairment. Investigations on environmental factors implicated in AD are scarce and the etiology of the disease remain...

    Authors: Federico Licastro, Ilaria Carbone, Elena Raschi and Elisa Porcellini

    Citation: Immunity & Ageing 2014 11:22

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  35. Content type: Research

    The use of autologous platelet gel in orthopedics is effective in accelerating the healing process of osteochondral, muscle, tendon and ligament lesions. The aim of our study was to verify whether the variabil...

    Authors: Claudia Rizzo, Roberta Vetro, Angelo Vetro, Roberto Mantia, Angelo Iovane, Marco Di Gesù, Sonya Vasto, Laura Di Noto, Giuseppina Mazzola and Calogero Caruso

    Citation: Immunity & Ageing 2014 11:21

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  36. Content type: Research

    Damage to T cells of the immune system by reactive oxygen species may result in altered cell function or cell death and thereby potentially impact upon the efficacy of a subsequent immune response. Here, we as...

    Authors: Shiva Marthandan, Robin Freeburn, Susanne Steinbrecht, Graham Pawelec and Yvonne Barnett

    Citation: Immunity & Ageing 2014 11:17

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  37. Content type: Research

    LMNA/C mutations have been linked to the premature aging syndrome Hutchinson’s progeria, dilated cardiomyopathy 1A, skeletal myopathies (such as the autosomal dominant variant of Emery-Dreifuss muscular dystrophy...

    Authors: Francesco Villa, Anna Maciąg, Chiara C Spinelli, Anna Ferrario, Albino Carrizzo, Attilio Parisi, Annalaura Torella, Chiara Montenero, Gianluigi Condorelli, Carmine Vecchione, Vincenzo Nigro, Annibale S Montenero and Annibale A Puca

    Citation: Immunity & Ageing 2014 11:19

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  38. Content type: Research

    Aging process is accompanied by a chronic sub-clinical systemic inflammation. This study aimed to assess the association between hearing impairment and polymorphisms of genes encoding cytokines deeply-committe...

    Authors: Yasue Uchida, Saiko Sugiura, Hiromi Ueda, Tsutomu Nakashima, Fujiko Ando and Hiroshi Shimokata

    Citation: Immunity & Ageing 2014 11:18

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  39. Content type: Research

    Although the incidence of spinal cord injury (SCI) is steadily rising in the elderly human population, few studies have investigated the effect of age in rodent models. Here, we investigated the effect of age ...

    Authors: Mitra J Hooshmand, Manuel D Galvan, Elizabeth Partida and Aileen J Anderson

    Citation: Immunity & Ageing 2014 11:15

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  40. Content type: Research

    A reduced number of naïve T cells along with an accumulation of differentiated cell types in aging have been described but little is known about the polyfunctionality of the T cell responses. In this study we ...

    Authors: Puja Van Epps, Richard Banks, Htin Aung, Michael R Betts and David H Canaday

    Citation: Immunity & Ageing 2014 11:14

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  41. Content type: Research

    The effect of the chronic stress of bereavement on immunity is poorly understood. Previous studies have demonstrated negative effects on immunity in older adults, and those who report higher depressive symptom...

    Authors: Ana Vitlic, Riyad Khanfer, Janet M Lord, Douglas Carroll and Anna C Phillips

    Citation: Immunity & Ageing 2014 11:13

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  42. Content type: Research

    T cell-dependent B-cell responses decline with age, indicating declined cognate helper activity of aged CD4 + T cells for B cells. However, the mechanisms remain unclear. T follicular helper (Tfh) cells, a nov...

    Authors: Maohua Zhou, Ruqiong Zou, Huiquan Gan, Zhimei Liang, Fujun Li, Ting Lin, Yanfei Luo, Xiaoming Cai, Fang He and Erxia Shen

    Citation: Immunity & Ageing 2014 11:12

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    The Erratum to this article has been published in Immunity & Ageing 2015 12:13

  43. Content type: Research

    Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also associated with increasing circulating lipid levels and intracellul...

    Authors: Joanne K Gardner, Cyril DS Mamotte, Terrence McGonigle, Danielle E Dye, Connie Jackaman and Delia J Nelson

    Citation: Immunity & Ageing 2014 11:11

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  44. Content type: Research

    The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two “enhanced vaccines” were licensed for individuals aged ≥65 years, one bein...

    Authors: Barbara Camilloni, Michela Basileo, Angela Di Martino, Isabella Donatelli and Anna Maria Iorio

    Citation: Immunity & Ageing 2014 11:10

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