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  1. Determining the prerequisites for healthy aging is a major task in the modern world characterized by a longer lifespan of the individuals. Besides lifestyle and environmental influences genetic factors are inv...

    Authors: Lutz Hamann, Juozas Kupcinskas, Luis C. Berrocal Almanza, Jurgita Skieceviciene, Andre Franke, Ute Nöthlings and Ralf R. Schumann
    Citation: Immunity & Ageing 2015 12:7

    The Erratum to this article has been published in Immunity & Ageing 2015 12:10

  2. Ineffective induction of T cell mediated immunity in older individuals remains a persistent challenge for vaccine development. Thus, there is a need for more efficient and sophisticated adjuvants that will com...

    Authors: Gee Jun Tye, Kyriaki Ioannou, Eunice Amofah, Ruby Quartey-Papafio, Samantha J. Westrop, Pramila Krishnamurthy, Alistair Noble, Phillip M. Harrison, Karin M.L. Gaensler, Linda D. Barber and Farzin Farzaneh
    Citation: Immunity & Ageing 2015 12:6
  3. Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bon...

    Authors: Fanny Pojero, Alessandra Casuccio, Francesco Di Bassiano, Francesco Gervasi, Giuseppina Colonna Romano and Calogero Caruso
    Citation: Immunity & Ageing 2015 12:5
  4. Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism caus...

    Authors: Simon Schneider, Werner Koch, Petra Hoppmann, Romy Ubrich, Stephan Kemmner, Eva Steinlechner, Uwe Heemann, Karl-Ludwig Laugwitz, Adnan Kastrati and Marcus Baumann
    Citation: Immunity & Ageing 2015 12:4
  5. The worldwide increase in life expectancy has been associated with an increase in age-related morbidities. The underlying mechanisms resulting in immunosenescence are only incompletely understood. Chronic vira...

    Authors: Kristie L Oxford, Myra Grace A dela Pena-Ponce, Kara Jensen, Meghan K Eberhardt, Abigail Spinner, Koen KA Van Rompay, Joseph Rigdon, Katie R Mollan, VV Krishnan, Michael G Hudgens, Peter A Barry and Kristina De Paris
    Citation: Immunity & Ageing 2015 12:3
  6. Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to pathogenesis and pathology of vascular-based neurodegenerative disorders such as Alzheimer’s disease. We recently reported in wild-typ...

    Authors: Mina Elahy, Connie Jackaman, John CL Mamo, Virginie Lam, Satvinder S Dhaliwal, Corey Giles, Delia Nelson and Ryusuke Takechi
    Citation: Immunity & Ageing 2015 12:2
  7. We originally cloned and identified murine Zizimin2 (Ziz2, Dock11) as a guanine nucleotide exchange factor (GEF) for Cdc42 and demonstrated that it activated the formation of filopodia. Since its expression pa...

    Authors: Takenori Matsuda, Shougo Yanase, Akinori Takaoka and Mitsuo Maruyama
    Citation: Immunity & Ageing 2015 12:1
  8. Cardiotrophin-1 (CT-1), a cytokine produced by cardiomyocytes and non-cardiomyocytes in conditions of stress, can be used as a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients...

    Authors: Monica Gioia Marazzi, Emanuela Galliera, Elena Vianello, Elena Dozio, Andrea Stella, Guido Tettamanti, Lorenza Tacchini and Massimiliano M Corsi Romanelli
    Citation: Immunity & Ageing 2014 11:27
  9. Ageing is accompanied by reduced immunity, termed immunesenescence. The immune system does not act in isolation and is sensitive to both psychological and physical stress. Hip fracture is a common physical str...

    Authors: Niharika Arora Duggal, Jane Upton, Anna C Phillips, Peter Hampson and Janet M Lord
    Citation: Immunity & Ageing 2014 11:25
  10. Tuberculosis, the disease due to Mycobacterium tuberculosis, is an important cause of morbidity and mortality in the elderly. Use of mouse models may accelerate insight into the disease and tests of therapies sin...

    Authors: David E Harrison, Clinton M Astle, M Khalid Khan Niazi, Samuel Major and Gillian L Beamer
    Citation: Immunity & Ageing 2014 11:24
  11. Despite significant medical progress and improved treatment, surgical procedures of proximal femur fractures in older patients are still associated with a high postoperative complication and mortality rate. Re...

    Authors: Helen Vester, Markus S Huber-Lang, Qerim Kida, Alexander Scola, Martijn van Griensven, Florian Gebhard, Andreas K Nüssler and Mario Perl
    Citation: Immunity & Ageing 2014 11:20
  12. Alzheimer’s disease (AD) is a complex disease resulting in neurodegeneration and cognitive impairment. Investigations on environmental factors implicated in AD are scarce and the etiology of the disease remain...

    Authors: Federico Licastro, Ilaria Carbone, Elena Raschi and Elisa Porcellini
    Citation: Immunity & Ageing 2014 11:22
  13. The use of autologous platelet gel in orthopedics is effective in accelerating the healing process of osteochondral, muscle, tendon and ligament lesions. The aim of our study was to verify whether the variabil...

    Authors: Claudia Rizzo, Roberta Vetro, Angelo Vetro, Roberto Mantia, Angelo Iovane, Marco Di Gesù, Sonya Vasto, Laura Di Noto, Giuseppina Mazzola and Calogero Caruso
    Citation: Immunity & Ageing 2014 11:21
  14. Damage to T cells of the immune system by reactive oxygen species may result in altered cell function or cell death and thereby potentially impact upon the efficacy of a subsequent immune response. Here, we as...

    Authors: Shiva Marthandan, Robin Freeburn, Susanne Steinbrecht, Graham Pawelec and Yvonne Barnett
    Citation: Immunity & Ageing 2014 11:17
  15. LMNA/C mutations have been linked to the premature aging syndrome Hutchinson’s progeria, dilated cardiomyopathy 1A, skeletal myopathies (such as the autosomal dominant variant of Emery-Dreifuss muscular dystrophy...

    Authors: Francesco Villa, Anna Maciąg, Chiara C Spinelli, Anna Ferrario, Albino Carrizzo, Attilio Parisi, Annalaura Torella, Chiara Montenero, Gianluigi Condorelli, Carmine Vecchione, Vincenzo Nigro, Annibale S Montenero and Annibale A Puca
    Citation: Immunity & Ageing 2014 11:19
  16. Aging process is accompanied by a chronic sub-clinical systemic inflammation. This study aimed to assess the association between hearing impairment and polymorphisms of genes encoding cytokines deeply-committe...

    Authors: Yasue Uchida, Saiko Sugiura, Hiromi Ueda, Tsutomu Nakashima, Fujiko Ando and Hiroshi Shimokata
    Citation: Immunity & Ageing 2014 11:18
  17. Although the incidence of spinal cord injury (SCI) is steadily rising in the elderly human population, few studies have investigated the effect of age in rodent models. Here, we investigated the effect of age ...

    Authors: Mitra J Hooshmand, Manuel D Galvan, Elizabeth Partida and Aileen J Anderson
    Citation: Immunity & Ageing 2014 11:15
  18. A reduced number of naïve T cells along with an accumulation of differentiated cell types in aging have been described but little is known about the polyfunctionality of the T cell responses. In this study we ...

    Authors: Puja Van Epps, Richard Banks, Htin Aung, Michael R Betts and David H Canaday
    Citation: Immunity & Ageing 2014 11:14
  19. The effect of the chronic stress of bereavement on immunity is poorly understood. Previous studies have demonstrated negative effects on immunity in older adults, and those who report higher depressive symptom...

    Authors: Ana Vitlic, Riyad Khanfer, Janet M Lord, Douglas Carroll and Anna C Phillips
    Citation: Immunity & Ageing 2014 11:13
  20. T cell-dependent B-cell responses decline with age, indicating declined cognate helper activity of aged CD4 + T cells for B cells. However, the mechanisms remain unclear. T follicular helper (Tfh) cells, a nov...

    Authors: Maohua Zhou, Ruqiong Zou, Huiquan Gan, Zhimei Liang, Fujun Li, Ting Lin, Yanfei Luo, Xiaoming Cai, Fang He and Erxia Shen
    Citation: Immunity & Ageing 2014 11:12

    The Erratum to this article has been published in Immunity & Ageing 2015 12:13

  21. Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also associated with increasing circulating lipid levels and intracellul...

    Authors: Joanne K Gardner, Cyril DS Mamotte, Terrence McGonigle, Danielle E Dye, Connie Jackaman and Delia J Nelson
    Citation: Immunity & Ageing 2014 11:11
  22. The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two “enhanced vaccines” were licensed for individuals aged ≥65 years, one bein...

    Authors: Barbara Camilloni, Michela Basileo, Angela Di Martino, Isabella Donatelli and Anna Maria Iorio
    Citation: Immunity & Ageing 2014 11:10
  23. CD4 T cell lymphopenia is an important T cell defect associated to ageing. Higher susceptibility to infections, cancer, or autoimmune pathologies described in aged individuals is thought to partly rely on T ce...

    Authors: Kim Zita Martinet, Stéphane Bloquet and Christine Bourgeois
    Citation: Immunity & Ageing 2014 11:8
  24. The prevalence of latex allergy varies according to the population studied from 3% to 64%. No data exist in the present literature about elderly people because they were not considered among populations at ris...

    Authors: Teresa Grieco, Valentina Faina, Laura Dies, Marzio Milana, Emidio Silvestri and Stefano Calvieri
    Citation: Immunity & Ageing 2014 11:7
  25. Aging process may result in immune modifications that lead to disruption of innate and acquired immunity mechanisms that may induce chronic-degenerative events. The heat shock proteins (Hsp), phylogeneticaly c...

    Authors: Estevam José Baldon, Eliana Blini Marengo, Marcelo de Franco, Nancy Starobinas, Valquiria Bueno and Osvaldo Augusto Sant’Anna
    Citation: Immunity & Ageing 2014 11:6
  26. The association between long-term exposure to air pollution and local inflammation in the lung has rarely been investigated in the general population of elderly subjects before. We investigated this associatio...

    Authors: Mohammad Vossoughi, Tamara Schikowski, Andrea Vierkötter, Dorothea Sugiri, Barbara Hoffmann, Tom Teichert, Christian Herder, Thomas Schulte, Christian Luckhaus, Monika Raulf-Heimsoth, Swaantje Casjens, Thomas Brüning and Ursula Krämer
    Citation: Immunity & Ageing 2014 11:5
  27. Many respiratory viruses disproportionately impact the elderly. Likewise, advanced age correlated with more adverse disease outcomes following severe acute respiratory syndrome coronavirus (SARS-CoV) infection...

    Authors: Candice C Clay, Nathan Donart, Ndingsa Fomukong, Jennifer B Knight, Katie Overheim, Jennifer Tipper, Jesse Van Westrienen, Fletcher Hahn and Kevin S Harrod
    Citation: Immunity & Ageing 2014 11:4
  28. Low-grade inflammatory state causes the development of the principal chronic-degenerative pathologies related with ageing. Consequently, it is required a better comprehension of the physiologic origins and the...

    Authors: Anna Maria Berghella, Ida Contasta, Giuseppe Marulli, Carlo D’Innocenzo, Ferdinando Garofalo, Francesca Gizzi, Marco Bartolomucci, Giacomo Laglia, Marisa Valeri, Mario Gizzi, Mauro Friscioni, Mario Barone, Tiziana Del Beato, Enzo Secinaro and Patrizia Pellegrini
    Citation: Immunity & Ageing 2014 11:3
  29. Infection with human cytomegalovirus (CMV) affects the function and composition of the immune system during ageing. In addition to the presence of the pathogen, the strength of the immune response, as measured...

    Authors: Saara Marttila, Juulia Jylhävä, Laura Kananen, Antti Hervonen, Marja Jylhä and Mikko Hurme
    Citation: Immunity & Ageing 2014 11:2
  30. Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and...

    Authors: Liina Tserel, Maia Limbach, Mario Saare, Kai Kisand, Andres Metspalu, Lili Milani and Pärt Peterson
    Citation: Immunity & Ageing 2014 11:1
  31. The pro-inflammatory status of the elderly triggers most of the age-related diseases such as cancer and atherosclerosis. Atherosclerosis, the leading cause world wide of morbidity and death, is an inflammatory...

    Authors: Lutz Hamann, Alexander Koch, Saubashya Sur, Nadja Hoefer, Christiane Glaeser, Susanne Schulz, Michael Gross, Andre Franke, Ute Nöthlings, Kai Zacharowski and Ralf R Schumann
    Citation: Immunity & Ageing 2013 10:43
  32. Aging of the immune system, known as immunosenescence, is associated with profound changes in both innate and adaptive immune responses, resulting in increased susceptibility to infection and a decreased abili...

    Authors: Aida Sivro, Julie Lajoie, Joshua Kimani, Walter Jaoko, Francis A Plummer, Keith Fowke and T Blake Ball
    Citation: Immunity & Ageing 2013 10:42
  33. Alzheimer’s Disease (AD) is a neurodegenerative disorder affecting up to one third of individuals reaching the age of 80. Different integrated responses exist in the brain to detect oxidative stress which is c...

    Authors: Carolin Cornelius, Angela Trovato Salinaro, Maria Scuto, Vincenzo Fronte, Maria Teresa Cambria, Manuela Pennisi, Rita Bella, Pietro Milone, Antonio Graziano, Rosalia Crupi, Salvatore Cuzzocrea, Giovanni Pennisi and Vittorio Calabrese
    Citation: Immunity & Ageing 2013 10:41
  34. Periodontitis is a multi-factorial disease and several risk-factors such as infections, inflammatory responses, oral hygiene, smoke, aging and individual predisposition are involved in the disease. Pathogens t...

    Authors: Manuela Ianni, Giacomo Bruzzesi, Davide Pugliese, Elisa Porcellini, Ilaria Carbone, Antonio Schiavone and Federico Licastro
    Citation: Immunity & Ageing 2013 10:39
  35. As the European population is getting older, there is growing need in scientific data on how to achieve healthy and successful aging. A decline in immune function with age is unanimously supported by many epid...

    Authors: Marie-Paule Vasson, Marie-Chantal Farges, Nicolas Goncalves-Mendes, Jérémie Talvas, Josep Ribalta, Brigitte Winklhofer-Roob, Edmond Rock and Adrien Rossary
    Citation: Immunity & Ageing 2013 10:38
  36. Declining telomere length (TL) is associated with T cell senescence. While TL in naïve and memory T cells declines with increasing age, there is limited data on TL dynamics in virus-specific memory CD4+ T cells i...

    Authors: Joel M O'Bryan, Marcia Woda, Mary Co, Anuja Mathew and Alan L Rothman
    Citation: Immunity & Ageing 2013 10:37
  37. CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor...

    Authors: Jiu Jiang, Erin Fisher and Donna M Murasko
    Citation: Immunity & Ageing 2013 10:36
  38. Natural Killer Cells (NK) play an important role in detection and elimination of virus-infected, damaged or cancer cells. NK cell function is guided by expression of Killer Immunoglobulin-like Receptors (KIRs)...

    Authors: Irene Maeve Rea, Lynn D Maxwell, Susan E McNerlan, H Denis Alexander, Martin D Curran, Derek Middleton and Owen A Ross
    Citation: Immunity & Ageing 2013 10:35
  39. Transfusion of autologous leukocytes after prolonged storage has been proposed as a means of rejuvenating the immune system of older individuals. The rationale for this approach is that age related immune decl...

    Authors: Richard Aspinall, Sheila Govind, Antonio Lapenna and Pierre Olivier Lang
    Citation: Immunity & Ageing 2013 10:34
  40. Sarcopenia is an important cause of morbidity and mortality in older adults, with immunosenescence and inflammation being possible underlying mechanisms. We investigated the relationship between latent cytomeg...

    Authors: Alixe HM Kilgour, Charlotte Firth, Rowan Harrison, Paul Moss, Mark E Bastin, Joanna M Wardlaw, Ian J Deary and John M Starr
    Citation: Immunity & Ageing 2013 10:33
  41. This study examines associations between markers of nutritional status and lymphocyte subsets and seeks to determine if lymphocyte profile is predictive of survival in elderly Australians residing in aged care...

    Authors: Julie L Woods, Sandra Iuliano-Burns and Karen Z Walker
    Citation: Immunity & Ageing 2013 10:32
  42. Studies about associations of infections with herpes viruses and other pathogens, such as Chlamydia pneumoniae (CP) and Helicobacter pylori (HP) with cardiovascular disease (CVD), diabetes mellitus (DM), frailty ...

    Authors: Michiel B Haeseker, Evelien Pijpers, Nicole HTM Dukers-Muijrers, Patty Nelemans, Christian JPA Hoebe, Cathrien A Bruggeman, Annelies Verbon and Valère J Goossens
    Citation: Immunity & Ageing 2013 10:30
  43. In rural sub-Saharan Africa, endemic populations are often infected concurrently with several intestinal and intravascular helminth and protozoan parasites. A specific, balanced and, to an extent, protective i...

    Authors: Christian J Lechner, Karl Komander, Jana Hegewald, Xiangsheng Huang, Richard G Gantin, Peter T Soboslay, Abram Agossou, Meba Banla and Carsten Köhler
    Citation: Immunity & Ageing 2013 10:29

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