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  1. Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system ...

    Authors: Danay Saavedra, Ana Laura Añé-Kourí, Nir Barzilai, Calogero Caruso, Kyung-Hyun Cho, Luigi Fontana, Claudio Franceschi, Daniela Frasca, Nuris Ledón, Laura J. Niedernhofer, Karla Pereira, Paul D. Robbins, Alexa Silva, Gisela M. Suarez, Wim Vanden Berghe, Thomas von Zglinicki…
    Citation: Immunity & Ageing 2023 20:25
  2. Dementia and frailty are common age-related syndromes often linked to chronic inflammation. Identifying the biological factors and pathways that contribute to chronic inflammation is crucial for developing new...

    Authors: Lolita S. Nidadavolu, Danielle Feger, Diefei Chen, Yuqiong Wu, Francine Grodstein, Alden L. Gross, David A. Bennett, Jeremy D. Walston, Esther S. Oh and Peter M. Abadir
    Citation: Immunity & Ageing 2023 20:24
  3. Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a consequence of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. S...

    Authors: Jeiny Luna Choconta, Verena Labi, Cristiana Dumbraveanu, Theodora Kalpachidou, Kai K. Kummer and Michaela Kress
    Citation: Immunity & Ageing 2023 20:22
  4. Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have pre...

    Authors: Jintao Zhuang, Xiangping Li, Jiahui Yao, Xiangzhou Sun, Jiumin Liu, Hua Nie, Yang Hu, Xiangan Tu, Huang Liu, Weibing Qin and Yun Xie
    Citation: Immunity & Ageing 2023 20:21
  5. Current influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for an ever-increasing aging population has been an arduous challenge due ...

    Authors: Bo Ryoung Park, Ramireddy Bommireddy, David Hyunjung Chung, Ki-Hye Kim, Jeeva Subbiah, Yu-Jin Jung, Noopur Bhatnagar, Christopher D. Pack, Sampath Ramachandiran, Shaker J.C. Reddy, Periasamy Selvaraj and Sang-Moo Kang
    Citation: Immunity & Ageing 2023 20:20
  6. Age-related accumulation of highly differentiated CD8+ effector memory re-expressing CD45RA (EMRA) T-cells and disruption of the kynurenine (KYN) pathway are associated with chronic inflammation and the developme...

    Authors: Tim Konstantin Boßlau, Paulina Wasserfurth, Thomas Reichel, Christopher Weyh, Jana Palmowski, Josefine Nebl, Niklas Joisten, Sergen Belen, Alexander Schenk, Andreas Hahn, Philipp Zimmer and Karsten Krüger
    Citation: Immunity & Ageing 2023 20:19
  7. Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination responses. Influenza (flu) is a leading killer of older adults despite...

    Authors: Dominique E. Martin, Andreia N. Cadar, Hunter Panier, Blake L. Torrance, George A. Kuchel and Jenna M. Bartley
    Citation: Immunity & Ageing 2023 20:18
  8. Advanced age is one of the significant risk determinants for coronavirus disease 2019 (COVID-19)-related mortality and for long COVID complications. The contributing factors may include the age-related dynamic...

    Authors: Ludmila Müller and Svetlana Di Benedetto
    Citation: Immunity & Ageing 2023 20:17
  9. Immunosenescence is a complex process characterized by an age-related remodelling of immune system. The prominent effects of the immunosenescence process is the thymic involution and, consequently, the decreas...

    Authors: Ersilia Paparazzo, Silvana Geracitano, Vincenzo Lagani, Luigi Citrigno, Denise Bartolomeo, Mirella Aurora Aceto, Francesco Bruno, Raffaele Maletta, Giuseppe Passarino and Alberto Montesanto
    Citation: Immunity & Ageing 2023 20:16
  10. A wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by mitochondria dysfunction is one of the significant factors associated with age....

    Authors: Kaiwu He, Lulin Nie, Tahir Ali, Zizhen Liu, Weifen Li, Ruyan Gao, Zena Zhang, Jianjun Liu, Zhongliang Dai, Yongmei Xie, Zaijun Zhang, Gongping Liu, Ming Dong, Zhi-Jian Yu, Shupeng Li and Xifei Yang
    Citation: Immunity & Ageing 2023 20:15
  11. Natural antibodies (nAbs) against aggregation-prone proteins have been found in healthy normal subjects. These proteins likely have a pathogenetic role in neurodegenerative diseases of ageing. They include the...

    Authors: Roberto Paganelli, Alessia Paganelli, Graham Pawelec and Angelo Di Iorio
    Citation: Immunity & Ageing 2023 20:13
  12. Glycyrrhizic acid (GA), a saponin compound often used as a flavoring agent, can elicit anti-inflammatory and anti-tumor effects, and alleviate aging. However, the specific mechanism by which GA alters immune c...

    Authors: Xue Gong, Haitao Shen, Liuling Guo, Ce Huang, Tingting Su, Hao Wang, Shengyu Feng, Shanshan Yang, Fenjiao Huo, Haifeng Liu, Jianbo Zhu, Jian-Kang Zhu, Hongbin Li and Hailiang Liu
    Citation: Immunity & Ageing 2023 20:12
  13. The progressive deregulation of the immune system with age, termed immunosenescence, has been well studied in mammalian systems, but studies of immune function in long-lived, wild, non-mammalian populations ar...

    Authors: Anne M. Bronikowski, Ashley R. Hedrick, Greta A. Kutz, Kaitlyn G. Holden, Beth Reinke and John B. Iverson
    Citation: Immunity & Ageing 2023 20:11
  14. The loss in age-related immunological markers, known as immunosenescence, is caused by a combination of factors, one of which is inflammaging. Inflammaging is associated with the continuous basal generation of...

    Authors: Ananya Ananya, Kaitlyn G. Holden, Zhiling Gu, Dan Nettleton, Surya K. Mallapragada, Michael J. Wannemuehler, Marian L. Kohut and Balaji Narasimhan
    Citation: Immunity & Ageing 2023 20:10
  15. Older people achieve lower levels of antibody titers than younger populations after Covid-19 vaccination and show a marked waning humoral immunity over time, likely due to the senescence of the immune system. ...

    Authors: María del Mar Pozo-Balado, Ángel Bulnes-Ramos, Israel Olivas-Martínez, Vanesa Garrido-Rodríguez, Carmen Lozano, Ana I. Álvarez-Ríos, Berta Sánchez-Sánchez, Encarnación Sánchez-Bejarano, Isabel Maldonado-Calzado, José Manuel Martín-Lara, Juan Antonio Santamaría, Rafael Bernal, María Francisca González-Escribano, Manuel Leal and Yolanda M. Pacheco
    Citation: Immunity & Ageing 2023 20:9
  16. Chronic kidney disease (CKD) is age-related disease, and decreased renal function is associated with the premature aging of T cells and increased incidence of other age-related diseases. However, the relations...

    Authors: Kenichiro Iio, Daijiro Kabata, Rei Iio, Shinichi Shibamoto, Yuuki Watanabe, Masashi Morita, Yosuke Imai, Masaki Hatanaka, Hiroki Omori and Yoshitaka Isaka
    Citation: Immunity & Ageing 2023 20:8
  17. Chronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated ...

    Authors: Bin Yang, Chengzhi Lv, Li Ye, Zhen Wang, Yoon Kim, Wenhai Luo, Peter M. Elias and Mao-Qiang Man
    Citation: Immunity & Ageing 2023 20:7
  18. Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and mortality. Little is known about the factors that contribute to the chronic inflammatory state associated with frailty. Extracell...

    Authors: Anjali M. Byappanahalli, Nicole Noren Hooten, Mya Vannoy, Nicolle A. Mode, Ngozi Ezike, Alan B. Zonderman and Michele K. Evans
    Citation: Immunity & Ageing 2023 20:6
  19. There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive de...

    Authors: Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars and Cobi J. Heijnen
    Citation: Immunity & Ageing 2023 20:5
  20. Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses.

    Authors: Charles T. Semelka, Michael E. DeWitt, Maria W. Blevins, Beth C. Holbrook, John W. Sanders and Martha A. Alexander-Miller
    Citation: Immunity & Ageing 2023 20:4
  21. The diffuse distribution of nicotinic cholinergic receptors (nAChRs) in both brain and peripheral immune cells points out their involvement in several pathological conditions. Indeed, the deregulated function ...

    Authors: E. Costantini, C. Carrarini, P. Borrelli, M. De Rosa, D. Calisi, S. Consoli, D. D’Ardes, F. Cipollone, M. Di Nicola, M. Onofrj, M. Reale and L. Bonanni
    Citation: Immunity & Ageing 2023 20:3
  22. The equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever previously recorded, and as methods to treat and manage elderly equids are developed and ...

    Authors: Sally DeNotta and Dianne McFarlane
    Citation: Immunity & Ageing 2023 20:2
  23. Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mt...

    Authors: Qian Liu, Zhenshu Li, Ling Huang, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang…
    Citation: Immunity & Ageing 2023 20:1
  24. Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of cognitive impairment as they age. Immune dysregulation, including inflammag...

    Authors: Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam M. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur and Eva L. Feldman
    Citation: Immunity & Ageing 2022 19:67

    The Correction to this article has been published in Immunity & Ageing 2024 21:16

  25. CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8+ T ...

    Authors: Min Sun Shin, Hong-Jai Park, Juan Young and Insoo Kang
    Citation: Immunity & Ageing 2022 19:66
  26. The risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease in hospitalised older patients may show significant variation, from mild to severe illne...

    Authors: M. Cardelli, E. Pierpaoli, F. Marchegiani, F. Marcheselli, F. Piacenza, R. Giacconi, R. Recchioni, T. Casoli, P. Stripoli, M. Provinciali, G. Matacchione, A. Giuliani, D. Ramini, J. Sabbatinelli, M. Bonafè, M. Di Rosa…
    Citation: Immunity & Ageing 2022 19:65
  27. Obesity is characterized by an elevated amount of fat and energy storage in the adipose tissue (AT) and is believed to be the root cause of many metabolic diseases (MDs). Obesity is associated with low-grade c...

    Authors: Ahmed Rakib, Sonia Kiran, Mousumi Mandal and Udai P. Singh
    Citation: Immunity & Ageing 2022 19:64
  28. It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it remains unclear whether aged monocytes, similar to aged T cells, have characteristics of hy...

    Authors: Yu Cao, Yang Fan, Fangyuan Li, Yu Hao, Yaxian Kong, Chen Chen, Xing Hao, Dannuo Han, Guoli Li, Zengtao Wang, Chuan Song, Junyan Han and Hui Zeng
    Citation: Immunity & Ageing 2022 19:63
  29. Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure of mitochondrial function in aging, with the temporal profile of serum high-sensitivity ...

    Authors: I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ling Chen, Pei-Fen Chen, Ray-Chin Wu, Chen-Wei Huang, Chao A. Hsiung and Chih-Cheng Hsu
    Citation: Immunity & Ageing 2022 19:62
  30. Authors: Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard…
    Citation: Immunity & Ageing 2022 19:61

    The original article was published in Immunity & Ageing 2022 19:57

  31. Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This study aimed to evaluate whether traumatic injury results in a state of prematurely aged...

    Authors: Mark A. Foster, Conor Bentley, Jon Hazeldine, Animesh Acharjee, Ornit Nahman, Shai S. Shen-Orr, Janet M. Lord and Niharika A. Duggal
    Citation: Immunity & Ageing 2022 19:60
  32. The sequestering of oxidation-modified low-density lipoprotein by macrophages results in the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes a release of intercellul...

    Authors: Joshua A. Taylor, Mark A. Hutchinson, Patricia J. Gearhart and Robert W. Maul
    Citation: Immunity & Ageing 2022 19:59
  33. Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction in T cell production and accumulation of atypical subsets. Ag...

    Authors: Mingxuan Chi, Zijun Tian, Kuai Ma, Yunlong Li, Li Wang, Moussa Ide Nasser and Chi Liu
    Citation: Immunity & Ageing 2022 19:58
  34. Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied thr...

    Authors: Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard…
    Citation: Immunity & Ageing 2022 19:57

    The Correction to this article has been published in Immunity & Ageing 2022 19:61

  35. Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescen...

    Authors: Sieun S. Kim, Jooyeon Sohn and Seung-Jae V. Lee
    Citation: Immunity & Ageing 2022 19:56
  36. Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for successful reproduction, and protection against sexually transmitted infections and po...

    Authors: Zheng Shen, Mickey V. Patel, Marta Rodriguez-Garcia and Charles R. Wira
    Citation: Immunity & Ageing 2022 19:55
  37. Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8+ T cells in CMV inf...

    Authors: Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi, Julia McKelvey, Alexei Sharov, Yu-Tsueng Liu, Jonathan Schneck and Nan-ping Weng
    Citation: Immunity & Ageing 2022 19:54
  38. Ageing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular senescence. Senescence of the immune system exacerbates individual’s immune response, ...

    Authors: Michał Cezary Czarnogórski, Justyna Sakowska, Mateusz Maziewski, Maciej Zieliński, Agnieszka Piekarska, Igor Obuchowski, Mikołaj Młyński, Magdalena Dutka, Alicja Sadowska-Klasa, Ewa Zarzycka, Maria Bieniaszewska, Piotr Trzonkowski, Jacek M. Witkowski, Andrzej Hellmann, Katarzyna Ruckemann-Dziurdzińska and Jan M. Zaucha
    Citation: Immunity & Ageing 2022 19:51
  39. Patients with systemic lupus erythematosus (SLE) are highly susceptible to infection and cardiovascular events, suggesting that chronic antigenic stimulation may accelerate premature aging in SLE patients. Pre...

    Authors: Ti Zhang, Xin Liu, Yue Zhao, Xiaodong Xu, Yaoyang Liu and Xin Wu
    Citation: Immunity & Ageing 2022 19:50
  40. Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life. A growing consensus supports the contribution of chronic infl...

    Authors: Orietta Pansarasa, Maria Chiara Mimmi, Annalisa Davin, Marta Giannini, Antonio Guaita and Cristina Cereda
    Citation: Immunity & Ageing 2022 19:49
  41. Aging and obesity are high risk factors for several conditions and diseases. They are both associated with systemic inflammation and they are both ameliorated by a healthy life style, suggesting that they may ...

    Authors: Daniela Frasca
    Citation: Immunity & Ageing 2022 19:48
  42. Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate the efficacy of COVID-19 vaccines (AZD-1222, Sputnik-V, Sinopharm, and Covaxin) and...

    Authors: Hamed Zare, Hadis Rezapour, Alireza Fereidouni, Saboura Nikpour, Sara Mahmoudzadeh, Simon G Royce and Mohammad Fereidouni
    Citation: Immunity & Ageing 2022 19:47
  43. Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to ...

    Authors: Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng and Haipeng Xiao
    Citation: Immunity & Ageing 2022 19:46
  44. Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and...

    Authors: Travis E. Hodges, Stephanie E. Lieblich, Rebecca K. Rechlin and Liisa A. M. Galea
    Citation: Immunity & Ageing 2022 19:43

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    Journal Impact Factor: 5.2
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    Source Normalized Impact per Paper (SNIP): 1.062
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