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  1. Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction in T cell production and accumulation of atypical subsets. Ag...

    Authors: Mingxuan Chi, Zijun Tian, Kuai Ma, Yunlong Li, Li Wang, Moussa Ide Nasser and Chi Liu
    Citation: Immunity & Ageing 2022 19:58
  2. Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied thr...

    Authors: Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard…
    Citation: Immunity & Ageing 2022 19:57

    The Correction to this article has been published in Immunity & Ageing 2022 19:61

  3. Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescen...

    Authors: Sieun S. Kim, Jooyeon Sohn and Seung-Jae V. Lee
    Citation: Immunity & Ageing 2022 19:56
  4. Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for successful reproduction, and protection against sexually transmitted infections and po...

    Authors: Zheng Shen, Mickey V. Patel, Marta Rodriguez-Garcia and Charles R. Wira
    Citation: Immunity & Ageing 2022 19:55
  5. Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8+ T cells in CMV inf...

    Authors: Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi, Julia McKelvey, Alexei Sharov, Yu-Tsueng Liu, Jonathan Schneck and Nan-ping Weng
    Citation: Immunity & Ageing 2022 19:54
  6. Ageing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular senescence. Senescence of the immune system exacerbates individual’s immune response, ...

    Authors: Michał Cezary Czarnogórski, Justyna Sakowska, Mateusz Maziewski, Maciej Zieliński, Agnieszka Piekarska, Igor Obuchowski, Mikołaj Młyński, Magdalena Dutka, Alicja Sadowska-Klasa, Ewa Zarzycka, Maria Bieniaszewska, Piotr Trzonkowski, Jacek M. Witkowski, Andrzej Hellmann, Katarzyna Ruckemann-Dziurdzińska and Jan M. Zaucha
    Citation: Immunity & Ageing 2022 19:51
  7. Patients with systemic lupus erythematosus (SLE) are highly susceptible to infection and cardiovascular events, suggesting that chronic antigenic stimulation may accelerate premature aging in SLE patients. Pre...

    Authors: Ti Zhang, Xin Liu, Yue Zhao, Xiaodong Xu, Yaoyang Liu and Xin Wu
    Citation: Immunity & Ageing 2022 19:50
  8. Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life. A growing consensus supports the contribution of chronic infl...

    Authors: Orietta Pansarasa, Maria Chiara Mimmi, Annalisa Davin, Marta Giannini, Antonio Guaita and Cristina Cereda
    Citation: Immunity & Ageing 2022 19:49
  9. Aging and obesity are high risk factors for several conditions and diseases. They are both associated with systemic inflammation and they are both ameliorated by a healthy life style, suggesting that they may ...

    Authors: Daniela Frasca
    Citation: Immunity & Ageing 2022 19:48
  10. Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate the efficacy of COVID-19 vaccines (AZD-1222, Sputnik-V, Sinopharm, and Covaxin) and...

    Authors: Hamed Zare, Hadis Rezapour, Alireza Fereidouni, Saboura Nikpour, Sara Mahmoudzadeh, Simon G Royce and Mohammad Fereidouni
    Citation: Immunity & Ageing 2022 19:47
  11. Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to ...

    Authors: Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng and Haipeng Xiao
    Citation: Immunity & Ageing 2022 19:46
  12. Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and...

    Authors: Travis E. Hodges, Stephanie E. Lieblich, Rebecca K. Rechlin and Liisa A. M. Galea
    Citation: Immunity & Ageing 2022 19:43
  13. Assessment of immune function is of key importance in recognition of disease or healthy status, which still faces challenge in clinical practice. We conducted a 10-center study to investigate lymphocyte parame...

    Authors: Wei Liu, Jie Xu, Qiyao Pu, Mingwei Lan, Xiaolu Zhang, Yufeng Gu, Ying Wang, Fan Zheng, Jingjing Qian, Chunxue Fan, Jun Sui, Yanli Xu, Yongchen Zhang, Jing Luo, Xiangyang Lin, Shaorui Shi…
    Citation: Immunity & Ageing 2022 19:42
  14. Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age. Although much of our current understanding of the age-related changes in...

    Authors: Ryan G. Snodgrass, Xiaowen Jiang and Charles B. Stephensen
    Citation: Immunity & Ageing 2022 19:41
  15. Aging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more susceptible to a variety of age-related diseases. A common cause of impa...

    Authors: Bastian Robinson Baarz, Thea Laurentius, Jana Wolf, Inga Wessels, Leo Cornelius Bollheimer and Lothar Rink
    Citation: Immunity & Ageing 2022 19:40
  16. Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death fo...

    Authors: Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney and George A. Kuchel
    Citation: Immunity & Ageing 2022 19:39
  17. Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determi...

    Authors: Miriam Retuerto, Ana Lledó, Beatriz Fernandez-Varas, Rosa Guerrero-López, Alicia Usategui, Antonio Lalueza, Rocío García-García, Esther Mancebo, Estela Paz-Artal, Leandro Sastre, Rosario Perona and José L. Pablos
    Citation: Immunity & Ageing 2022 19:38
  18. Traditionally, the immune system is understood to be divided into discrete cell types that are identified via surface markers. While some cell type distinctions are no doubt discrete, others may in fact vary o...

    Authors: G. Provost, F. B. Lavoie, A. Larbi, TP. Ng, C. Tan Tze Ying, M. Chua, T. Fulop and A. A. Cohen
    Citation: Immunity & Ageing 2022 19:35
  19. The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the mechanisms underlying age-related T cell infiltr...

    Authors: Xiaotao Zhang, Rui Wang, Haoran Chen, Chenghao Jin, Ziyang Jin, Jianan Lu, Liang Xu, Yunrong Lu, Jianmin Zhang and Ligen Shi
    Citation: Immunity & Ageing 2022 19:34
  20. Cellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenotype (ARIP) characterized by decrease in naïve T-cells (TN) and increase in memory T-cells ...

    Authors: Ramya Ramasubramanian, Helen C. S. Meier, Sithara Vivek, Eric Klopack, Eileen M. Crimmins, Jessica Faul, Janko Nikolich-Žugich and Bharat Thyagarajan
    Citation: Immunity & Ageing 2022 19:33
  21. Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with cell-division and ageing. T and B-cells cells are...

    Authors: Pam S. Ellis, Raquel R. Martins, Emily J. Thompson, Asma Farhat, Stephen A. Renshaw and Catarina M. Henriques
    Citation: Immunity & Ageing 2022 19:31
  22. Authors: Grace M. Niemiro, Adriana M. Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M. Brewster, Therese B. Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C. Gilchrist and Richard J. Simpson
    Citation: Immunity & Ageing 2022 19:30

    The original article was published in Immunity & Ageing 2022 19:17

  23. Grass carp are an important farmed fish in China that are infected by many pathogens, especially grass carp reovirus (GCRV). Notably, grass carp showed age-dependent susceptibility to GCRV; that is, grass carp...

    Authors: Libo He, Xinyu Liang, Qian Wang, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu and Yaping Wang
    Citation: Immunity & Ageing 2022 19:28
  24. Influenza causes a serious infection in older individuals who are at the highest risk for mortality from this virus. Changes in the immune system with age are well known. This study used transcriptomic analysi...

    Authors: Ana M. Hernandez, Jim A. Mossman, Franklin R. Toapanta, Dana M. Previte, Ted M. Ross and Gerard J. Nau
    Citation: Immunity & Ageing 2022 19:27
  25. With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting tha...

    Authors: Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney and Chris P. Verschoor
    Citation: Immunity & Ageing 2022 19:26
  26. Understanding mechanisms of pathologic neuroinflammation is essential for improving outcomes after central nervous system infections. Brain tissue-resident memory T cells (bTRM) are recruited during central nervo...

    Authors: Benjamin R. Cassidy, William E. Sonntag, Pieter J. M. Leenen and Douglas A. Drevets
    Citation: Immunity & Ageing 2022 19:25
  27. The existence of SARS-CoV-2 variants of concern (VOCs) in association with evidence of breakthrough infections despite vaccination resulted in the need for vaccine boosting. In elderly individuals, information...

    Authors: Chalerm Liwsrisakun, Supansa Pata, Witida Laopajon, Nuchjira Takheaw, Warawut Chaiwong, Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Kantinan Chuensirikulchai and Watchara Kasinrerk
    Citation: Immunity & Ageing 2022 19:24
  28. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular...

    Authors: Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal Desai, Michael C. Honigberg, Shelly-Ann Love, Ana Barac, Kathleen M. Hayden, JoAnn E. Manson, Eric A. Whitsel, Charles Kooperberg, Pradeep Natarajan, Alexander P. Reiner and Jacob O. Kitzman
    Citation: Immunity & Ageing 2022 19:23
  29. Highly contagious respiratory diseases caused by viral infections are a constantly emerging threat, particularly the elderly with the higher risk of developing serious complications. Vaccines are the best stra...

    Authors: Jihyun Yang, Jaemoo Kim, Chaewon Kwak and Haryoung Poo
    Citation: Immunity & Ageing 2022 19:22
  30. Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and ...

    Authors: Zhigao Sun, Jieqiong Lin, Yujie Zhang, Yao Yao, Zhenjun Huang, Yali Zhao, Pei Zhang and Shihui Fu
    Citation: Immunity & Ageing 2022 19:21
  31. NF-κB is generally recognized as an important regulator of ageing, through its roles in cellular senescence and inflammatory pathways. Activated in virtually all cell-cell communication networks of the immune ...

    Authors: Preeyaporn Songkiatisak, Shah Md Toufiqur Rahman, Mohammad Aqdas and Myong-Hee Sung
    Citation: Immunity & Ageing 2022 19:20
  32. It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers. Although mucosal...

    Authors: Camille Khairallah, Timothy H. Chu, Zhijuan Qiu, Jessica N. Imperato, Daniella Yang and Brian S. Sheridan
    Citation: Immunity & Ageing 2022 19:19
  33. NKT-like cells are T lymphocytes coexpressing several NK cell-associated receptors. They are effector lymphocytes of innate and adaptive immunity, and their number increases with age. The study aimed to analyz...

    Authors: Lucyna Kaszubowska, Jerzy Foerster and Zbigniew Kmieć
    Citation: Immunity & Ageing 2022 19:18
  34. Immunosenescence is described as age-associated changes within the immune system that are responsible for decreased immunity and increased cancer risk. Physically active individuals have fewer ‘senescent’ and ...

    Authors: Grace M Niemiro, Adriana M Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M Brewster, Therese B Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C Gilchrist and Richard J. Simpson
    Citation: Immunity & Ageing 2022 19:17

    The Correction to this article has been published in Immunity & Ageing 2022 19:30

  35. Amongst other systemic changes, aging leads to an immune dysfunction. On the molecular level, a hallmark of aging is telomere shortening. The functional relevance of telomerase, an enzyme capable of elongating...

    Authors: Diana M. Matthe, Oana-Maria Thoma, Tobias Sperka, Markus F. Neurath and Maximilian J. Waldner
    Citation: Immunity & Ageing 2022 19:16
  36. As we age, the functioning of the human immune system declines. The results of this are increases in morbidity and mortality associated with infectious diseases, cancer, cardiovascular disease, and neurodegene...

    Authors: Arttu Autio, Jalmari Kettunen, Tapio Nevalainen, Bryn Kimura and Mikko Hurme
    Citation: Immunity & Ageing 2022 19:15
  37. Despite the high incidence of fractures and pseudoarthrosis in the aged population, a potential role for the use of mesenchymal stem cells (MSCs) in the treatment of bone defects in elderly patients has not be...

    Authors: Hirohito Hirata, Ning Zhang, Masaya Ueno, Danial Barati, Junichi Kushioka, Huaishuang Shen, Masanori Tsubosaka, Masakazu Toya, Tzuhua Lin, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang and Stuart B. Goodman
    Citation: Immunity & Ageing 2022 19:14
  38. Chronic cytomegalovirus (CMV) infection has been postulated as a driver of chronic inflammation that has been associated with frailty and other age-related conditions in both HIV-infected (HIV+) and -uninfecte...

    Authors: Weiying Zhang, Huifen Li, Jay H. Bream, Tricia L. Nilles, Sean X. Leng and Joseph B. Margolick
    Citation: Immunity & Ageing 2022 19:13
  39. COVID-19 patients may experience “cytokine storm” when human immune system produces excessive cytokines/chemokines. However, it remains unclear whether early responses of inflammatory cytokines would lead to h...

    Authors: Xixi Jing, Min Xu, Deye Song, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq and Guangdi Li
    Citation: Immunity & Ageing 2022 19:12
  40. γδ T cells are a highly versatile immune lineage involved in host defense and homeostasis, but questions remain around their heterogeneity, precise function and role during health and disease. We used multiparam...

    Authors: Amali Karunathilaka, Samuel Halstrom, Patricia Price, Michael Holt, Viviana P. Lutzky, Denise L. Doolan, Andreas Kupz, Scott C. Bell, Rachel M. Thomson, John J. Miles and Champa N. Ratnatunga
    Citation: Immunity & Ageing 2022 19:11
  41. Chronic inflammation might play a major role in the pathogenesis linking diabetes mellitus (DM) to cognition. In addition, DM might be the main driver of dementia risk. The purpose of the present study was to ...

    Authors: Yen-Chun Fan, Chia-Chi Chou, Bagas Suryo Bintoro, Kuo-Liong Chien and Chyi-Huey Bai
    Citation: Immunity & Ageing 2022 19:10
  42. COPD is associated with an abnormal lung immune response that leads to tissue damage and remodeling of the lung, but also to systemic effects that compromise immune responses. Cigarette smoking also impacts on...

    Authors: Juliana Ruiz Fernandes, Thalyta Nery Carvalho Pinto, Liã Barbara Arruda, Cibele Cristine Berto Marques da Silva, Celso Ricardo Fernandes de Carvalho, Regina Maria Carvalho Pinto, Alberto José da Silva Duarte and Gil Benard
    Citation: Immunity & Ageing 2022 19:9

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