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  1. Alzheimer’s disease (AD) is one of the most frequent cause of neurodegenerative disorder in the elderly. Inflammation has been implicated in brain degenerative processes and peripheral markers of brain AD rela...

    Authors: Manuela Ianni, Marcella Manerba, Giuseppina Di Stefano, Elisa Porcellini, Martina Chiappelli, Ilaria Carbone and Federico Licastro
    Citation: Immunity & Ageing 2010 7(Suppl 1):S6

    This article is part of a Supplement: Volume 7 Supplement 1

  2. The population longitudinal study named “The Conselice Study” has been the focus of the present investigation. 65 years old or older participants of this population study on brain aging were followed up for 5 ...

    Authors: Federico Licastro, Elisa Porcellini, Paola Forti, Massimo Buscema, Ilaria Carbone, Giovanni Ravaglia and Enzo Grossi
    Citation: Immunity & Ageing 2010 7(Suppl 1):S4

    This article is part of a Supplement: Volume 7 Supplement 1

  3. Among the age-related diseases, the development of cognitive impairments, in particular dementia, is the most devastating for the individual and has great social and healthcare costs. Accurate information is n...

    Authors: Giovanni Ravaglia and Paola Forti
    Citation: Immunity & Ageing 2010 7(Suppl 1):S2

    This article is part of a Supplement: Volume 7 Supplement 1

  4. Periodontal disease is a chronic inflammatory gum disease that in severe cases leads to tooth loss. Porphyromonas gingivalis (Pg) is a bacterium closely associated with generalized forms of periodontal disease. C...

    Authors: Yazdani B Shaik-Dasthagirisaheb, Alpdogan Kantarci and Frank C Gibson III
    Citation: Immunity & Ageing 2010 7:15
  5. Respiratory syncytial virus (RSV) is the major pathogen causing respiratory disease in young infants and it is an important cause of serious illness in the elderly since the infection provides limited immune p...

    Authors: Maria Grazia Cusi, Barbara Martorelli, Giuseppa Di Genova, Chiara Terrosi, Giuseppe Campoccia and Pierpaolo Correale
    Citation: Immunity & Ageing 2010 7:14
  6. The tuberculosis (TB) still increases in the number of new cases, which is estimated to approach 10 million in 2010. The number of aged people has been growing all over the world. Ageing is one of risk factors...

    Authors: Tsukasa Ito, Takemasa Takii, Mitsuo Maruyama, Daisuke Hayashi, Takeshi Wako, Azusa Asai, Yasuhiro Horita, Keiichi Taniguchi, Ikuya Yano, Saburo Yamamoto and Kikuo Onozaki
    Citation: Immunity & Ageing 2010 7:12
  7. Immunoglobulin A (IgA) secretion in saliva decreases with age and may be the cause of increased vulnerability of the elderly to respiratory infections. The effect of oral intake of lactic acid bacteria on sali...

    Authors: Yoshifumi Kotani, Shoji Shinkai, Hiroshi Okamatsu, Masamichi Toba, Kishiko Ogawa, Hiroto Yoshida, Taro Fukaya, Yoshinori Fujiwara, Paulo HM Chaves, Keiji Kakumoto and Noriyuki Kohda
    Citation: Immunity & Ageing 2010 7:11
  8. The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a ...

    Authors: Régine Minet-Quinard, M Chantal Farges, Emilie Thivat, Cécile Deleine, Gilles Mayot, Julius Brtko, Josep Ribalta, Brigitte Winklhofer-Roob, Edmond Rock and M Paule Vasson
    Citation: Immunity & Ageing 2010 7:10
  9. Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of ...

    Authors: Thi Kim Duy Vo, Patrice Godard, Marie de Saint-Hubert, Gabriel Morrhaye, Christian Swine, Vincent Geenen, Henri J Martens, Florence Debacq-Chainiaux and Olivier Toussaint
    Citation: Immunity & Ageing 2010 7:9
  10. The increasing ratio of ageing population poses new challenges to healthcare systems. The elderly frequently suffer from severe infections. Vaccination could protect them against several infectious diseases, b...

    Authors: Joseph Ongrádi and Valéria Kövesdi
    Citation: Immunity & Ageing 2010 7:7
  11. There is reported to be a decline in immune function and an alteration in the frequency of circulating lymphocytes with advancing age. There are also differences in ageing and lifespan between males and female...

    Authors: Jun Yan, Judith M Greer, Renee Hull, John D O'Sullivan, Robert D Henderson, Stephen J Read and Pamela A McCombe
    Citation: Immunity & Ageing 2010 7:4
  12. Oncogenic γ-herpesviruses establish life-long infections in their hosts and control of these latent infections is dependent on continual immune surveillance. Immune function declines with age, raising the poss...

    Authors: Eric J Yager, In-Jeong Kim, Michael L Freeman, Kathleen G Lanzer, Claire E Burkum, Tres Cookenham, David L Woodland and Marcia A Blackman
    Citation: Immunity & Ageing 2010 7:3
  13. The prevalence of coronary artery diseases is low among Down Syndrome (DS) patients and they rarely die of atherosclerotic complications. Histopathological investigations showed no increase in atherosclerosis,...

    Authors: Giada Dogliotti, Emanuela Galliera, Federico Licastro and Massimiliano M Corsi
    Citation: Immunity & Ageing 2010 7:2
  14. A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini...

    Authors: E Sikora, Giovanni Scapagnini and Mario Barbagallo
    Citation: Immunity & Ageing 2010 7:1
  15. The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.

    Authors: Francesco Iemolo, Giovanni Duro, Claudia Rizzo, Laura Castiglia, Vladimir Hachinski and Calogero Caruso
    Citation: Immunity & Ageing 2009 6:13
  16. A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here ...

    Authors: Giuseppina Campisi, Martina Chiappelli, Massimo De Martinis, Vito Franco, Lia Ginaldi, Rosario Guiglia, Federico Licastro and Domenico Lio
    Citation: Immunity & Ageing 2009 6:12
  17. Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus (CMV) is one of the factors that affect functionality of T cells and the differentia...

    Authors: María Luisa Pita-Lopez, Inmaculada Gayoso, Olga DelaRosa, Javier G Casado, Corona Alonso, Elisa Muñoz-Gomariz, Raquel Tarazona and Rafael Solana
    Citation: Immunity & Ageing 2009 6:11
  18. On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B...

    Authors: Calogero Caruso, Silvio Buffa, Giuseppina Candore, Giuseppina Colonna-Romano, Deborah Dunn-Walters, David Kipling and Graham Pawelec
    Citation: Immunity & Ageing 2009 6:10
  19. The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging...

    Authors: Hajo Haase and Lothar Rink
    Citation: Immunity & Ageing 2009 6:9
  20. Rheumatoid arthritis (RA) most often begins in females in the fourth-fifth decade of their life, suggesting that the aging of the immune system (immunosenescence) has a major role in this disease. Therefore, i...

    Authors: Oktavia Tarjanyi, Ferenc Boldizsar, Peter Nemeth, Katalin Mikecz and Tibor T Glant
    Citation: Immunity & Ageing 2009 6:8
  21. The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic infla...

    Authors: Linda May, Anita HJ van den Biggelaar, David van Bodegom, Hans J Meij, Anton JM de Craen, Joseph Amankwa, Marijke Frölich, Maris Kuningas and Rudi GJ Westendorp
    Citation: Immunity & Ageing 2009 6:7
  22. A method is described that allows an accurate mapping of 3' ends of RNAs. In this method a labeled DNA probe, containing the presumed 3' end of the RNA under analysis is allowed to anneals to the RNA itself. M...

    Authors: Daniele Bellavia, Giorgia Sisino, Giorgio L Papadopoulos, Giusi I Forte and Rainer Barbieri
    Citation: Immunity & Ageing 2009 6:6
  23. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Mutations in two genes, LMNA and ZMPSTE24,...

    Authors: Henrique Douglas M Coutinho, Vivyanne S Falcão-Silva, Gregório Fernandes Gonçalves and Raphael Batista da Nóbrega
    Citation: Immunity & Ageing 2009 6:4
  24. Ageing leads to a decline in the function of the immune system, increasing the body's susceptibility to infections through the impairment of T-cells, macrophages, neutrophils and dendritic cells Denture stomat...

    Authors: Thaís Helena Gasparoto, Narciso Almeida Vieira, Vinicius Carvalho Porto, Ana Paula Campanelli and Vanessa Soares Lara
    Citation: Immunity & Ageing 2009 6:3
  25. Immunosenescence is an age-associated disorder occurring primarily in T cell compartments, including altered subset composition, functions, and activation. In women, evidence implicates diminished estrogen in ...

    Authors: Lowell T Ku, Cicek Gercel-Taylor, Steven T Nakajima and Douglas D Taylor
    Citation: Immunity & Ageing 2009 6:1
  26. Ageing is associated with dysfunction in the humoral response leading to decreased protection against infectious diseases. Defects in T cell function due to age have been well characterized but it is unclear i...

    Authors: Anthony Blaeser, Kiley McGlauchlen and Laura A Vogel
    Citation: Immunity & Ageing 2008 5:15
  27. Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection wit...

    Authors: Angelika Schwanninger, Birgit Weinberger, Daniela Weiskopf, Dietmar Herndler-Brandstetter, Stephan Reitinger, Christoph Gassner, Harald Schennach, Walther Parson, Reinhard Würzner and Beatrix Grubeck-Loebenstein
    Citation: Immunity & Ageing 2008 5:14
  28. Reactive oxygen species (ROS), including free radicals, oxygen ions, and peroxides, are implicated in cell damage. The objective of this study was to investigate whether the spontaneous production of ROS from ...

    Authors: Kishiko Ogawa, Katsuhiko Suzuki, Mitsuharu Okutsu, Kyoko Yamazaki and Shoji Shinkai
    Citation: Immunity & Ageing 2008 5:13
  29. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is ass...

    Authors: Daniela Mari, Giulia Ogliari, Davide Castaldi, Giovanni Vitale, Elisa Mariadele Bollini and Domenico Lio
    Citation: Immunity & Ageing 2008 5:12
  30. Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon con...

    Authors: Evelyna Derhovanessian, Rafael Solana, Anis Larbi and Graham Pawelec
    Citation: Immunity & Ageing 2008 5:11
  31. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represe...

    Authors: Vittorio Nicita-Mauro, Giorgio Basile, Giuseppe Maltese, Claudio Nicita-Mauro, Sebastiano Gangemi and Calogero Caruso
    Citation: Immunity & Ageing 2008 5:10
  32. During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a ste...

    Authors: Matteo Bulati, Mariavaleria Pellicanò, Sonya Vasto and Giuseppina Colonna-Romano
    Citation: Immunity & Ageing 2008 5:9
  33. On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lectures of M. Racchi on History and future perspectives of Alzheimer Biomarkers and of...

    Authors: Marco Racchi, Daniela Uberti, Stefano Govoni, Maurizio Memo, Cristina Lanni, Sonya Vasto, Giuseppina Candore, Calogero Caruso, Loriana Romeo and Giovanni Scapagnini
    Citation: Immunity & Ageing 2008 5:7
  34. T cell-mediated immunity in elderly people is compromised in ways reflected in the composition of the peripheral T cell pool. The advent of polychromatic flow cytometry has made analysis of cell subsets feasib...

    Authors: Sven Koch, Anis Larbi, Evelyna Derhovanessian, Dennis Özcelik, Elissaveta Naumova and Graham Pawelec
    Citation: Immunity & Ageing 2008 5:6
  35. Chronic inflammation is a well-known corollary of the aging process and is believed to significantly contribute to morbidity and mortality of many age-associated chronic diseases. However, the mechanisms that ...

    Authors: Andres Kriete, Kelli L Mayo, Nirupama Yalamanchili, William Beggs, Patrick Bender, Csaba Kari and Ulrich Rodeck
    Citation: Immunity & Ageing 2008 5:5
  36. Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) plays an important role in regulation of endothelial function and in the control of blood pressure. However, the results from some stud...

    Authors: Daniela Colomba, Giovanni Duro, Salvatore Corrao, Christiano Argano, Tiziana Di Chiara, Domenico Nuzzo, Federica Pizzo, Gaspare Parrinello, Rosario Scaglione and Giuseppe Licata
    Citation: Immunity & Ageing 2008 5:4
  37. The safety and immunogenicity of an MF59™-adjuvanted subunit influenza vaccine (Sub/MF59™; FLUAD®, Novartis Vaccines) was evaluated among elderly Chinese subjects (≥ 60 years of age). After a preliminary Phase I,...

    Authors: Rongcheng Li, Hanhua Fang, Yanping Li, Youping Liu, Michele Pellegrini and Audino Podda
    Citation: Immunity & Ageing 2008 5:2
  38. The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly peo...

    Authors: Richard Aspinall, Giuseppe Del Giudice, Rita B Effros, Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara
    Citation: Immunity & Ageing 2007 4:9
  39. The mechanism explaining the increased disease susceptibility in aging is not well understood. CD8+ T cells are crucial in anti-viral and anti-tumor responses. Although the chemokine system plays a critical ro...

    Authors: Raymond Yung, RuRan Mo, Annabelle Grolleau-Julius and Mark Hoeltzel
    Citation: Immunity & Ageing 2007 4:8

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